Abstract
The release profiles of l-phenylalanine and metronidazole from individual microspheres conform to the Higuchi model for release by leaching of drugs from granular spherical pellets. The release profiles from a population of microspheres also conformed to the Higuchi model. The agreement between the Higuchi parameters for the cumulative release profile and that of a simple mathematical profile obtained by addition of the individual profiles suggests that the release mechanism of a population is identical to the mechanism of release from individuals that comprise the population.
| Original language | English |
|---|---|
| Pages (from-to) | 215-220 |
| Number of pages | 6 |
| Journal | Journal of Controlled Release |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 1990 |
Keywords
- Higuchi model
- albumin
- individual, population kinetics
- microspheres
- sustained release pattern