Replicating RNA duplexes and the epigenetic address

One can account for the stability of the differentiated state of the cell by assuming that the nucleus contains self-regenerating RNA/RNA duplexes which specify the state of differentiation of that cell-i.e. its epigenetic address. One strand of the duplex, address RNA, controls the processing of mRNA by binding specific sequences in gene transcripts. The complementary strand, c-address RNA, controls processing of address RNA transcripts, thereby regenerating the duplex. Epigenetic transformation occurs when an epigenetic signal directs the replacement of the current RNA/RNA duplex, guided by information carried on that duplex, in accordance with information carried on the genome.