Report of Consensus Panel 6 from the 11 th International Workshop on Waldenström's Macroglobulinemia on Management of Waldenström's Macroglobulinemia Related Amyloidosis

Giampaolo Merlini*, Shayna Sarosiek, Giulia Benevolo, Xinxin Cao, Meletios Dimopoulos, Ramon Garcia-Sanz, Moshe E. Gatt, Carlos Fernandez de Larrea, Jesus San-Miguel, Steven P. Treon, Monique C. Minnema

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Consensus Panel 6 (CP6) of the 11th International Workshop on Waldenström's Macroglobulinemia (IWWM-11) was tasked with reviewing the state of the art for diagnosis, prognosis, and therapy of AL amyloidosis associated with Waldenström macroglobulinemia (WM). Since significant advances have been made in the management of AL amyloidosis an update for this rare disease associated with WM was necessary. The key recommendations from IWWM-11 CP6 included: (1) The need to improve the diagnostic process by recognizing red flags and using biomarkers and imaging; (2) The essential tests for appropriate workup; (3) The diagnostic flowchart, including mandatory amyloid typing, that improves the differential diagnosis with transthyretin amyloidosis; (4) Criteria for therapy response assessment; (5) State of the art of the treatment including therapy of wild type transthyretin amyloidosis associated with WM.

Original languageAmerican English
Pages (from-to)113-117
Number of pages5
JournalSeminars in Hematology
Volume60
Issue number2
DOIs
StatePublished - Mar 2023

Bibliographical note

Funding Information:
The authors gratefully acknowledge Beigene Pharmaceuticals, Abbvie/Pharmacyclics, Janssen Pharmaceuticals, the International Waldenström's Macroglobulinemia Foundation, and Cellectar Biosciences, Inc. for their support of the 11th International Workshop on Waldenström's Macroglobulinemia. Consensus panel reports of IWWM-11 are for educational purposes and should not be construed as offering specific medical advice for patients.

Publisher Copyright:
© 2023 Elsevier Inc.

Keywords

  • AL amyloidosis
  • Diagnostic criteria
  • Response assessment
  • Therapy
  • Waldenström macroglobulinemia

Fingerprint

Dive into the research topics of 'Report of Consensus Panel 6 from the 11 th International Workshop on Waldenström's Macroglobulinemia on Management of Waldenström's Macroglobulinemia Related Amyloidosis'. Together they form a unique fingerprint.

Cite this