Repression of the heavy ferritin chain increases the labile iron pool of human K562 cells

O. Kakhlon, Y. Gruenbaum, Z. I. Cabantchik*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    46 Scopus citations

    Abstract

    The role of ferritin the modulation of the labile iron pool was examined by repressing the heavy subunit of ferritin in K562 cells transfected with an antisense construct. Repression of the heavy ferritin subunit evoked an increase in the chemical levels and pro-oxidant activity of the labile iron pool and, in turn, caused a reduced expression of transferrin receptors and increased expression of the light ferritin subunit.

    Original languageAmerican English
    Pages (from-to)311-316
    Number of pages6
    JournalBiochemical Journal
    Volume356
    Issue number2
    DOIs
    StatePublished - 1 Jun 2001

    Keywords

    • Antisense
    • Flourescence detection of metals
    • Transfection

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