Repression of the heavy ferritin chain increases the labile iron pool of human K562 cells

O. Kakhlon; Y. Gruenbaum; Z. I. Cabantchik

doi:10.1042/0264-6021:3560311

Repression of the heavy ferritin chain increases the labile iron pool of human K562 cells

O. Kakhlon, Y. Gruenbaum, Z. I. Cabantchik^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

The role of ferritin the modulation of the labile iron pool was examined by repressing the heavy subunit of ferritin in K562 cells transfected with an antisense construct. Repression of the heavy ferritin subunit evoked an increase in the chemical levels and pro-oxidant activity of the labile iron pool and, in turn, caused a reduced expression of transferrin receptors and increased expression of the light ferritin subunit.

Original language	American English
Pages (from-to)	311-316
Number of pages	6
Journal	Biochemical Journal
Volume	356
Issue number	2
DOIs	https://doi.org/10.1042/0264-6021:3560311
State	Published - 1 Jun 2001

Keywords

Antisense
Flourescence detection of metals
Transfection

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abstract = "The role of ferritin the modulation of the labile iron pool was examined by repressing the heavy subunit of ferritin in K562 cells transfected with an antisense construct. Repression of the heavy ferritin subunit evoked an increase in the chemical levels and pro-oxidant activity of the labile iron pool and, in turn, caused a reduced expression of transferrin receptors and increased expression of the light ferritin subunit.",

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AB - The role of ferritin the modulation of the labile iron pool was examined by repressing the heavy subunit of ferritin in K562 cells transfected with an antisense construct. Repression of the heavy ferritin subunit evoked an increase in the chemical levels and pro-oxidant activity of the labile iron pool and, in turn, caused a reduced expression of transferrin receptors and increased expression of the light ferritin subunit.

KW - Antisense

KW - Flourescence detection of metals

KW - Transfection

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ER -

Repression of the heavy ferritin chain increases the labile iron pool of human K562 cells

Abstract

Keywords

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