TY - JOUR
T1 - Requirements for sod mimics operating in vitro to work also in vivo
AU - Czapski, Gidon
AU - Goldstein, Sara
PY - 1991
Y1 - 1991
N2 - When an efficient SOD mimic operating in vitro is introduced into cells, the following requirements are needed in order that this compound will catalyze O-2 dismutation efficiently: it should be non toxic, stable, has a long metabolic half life, does not form ternary complexes with the cell components, its reduced form reacts slowly with molecular oxygen. should be able to cross cell membranes and also to reach lipophilic or hydrophobic regions. Thus, it seems that finding an efficient compound that has high SOD-like activity in vivo will not be easily achieved.
AB - When an efficient SOD mimic operating in vitro is introduced into cells, the following requirements are needed in order that this compound will catalyze O-2 dismutation efficiently: it should be non toxic, stable, has a long metabolic half life, does not form ternary complexes with the cell components, its reduced form reacts slowly with molecular oxygen. should be able to cross cell membranes and also to reach lipophilic or hydrophobic regions. Thus, it seems that finding an efficient compound that has high SOD-like activity in vivo will not be easily achieved.
KW - Catalysis
KW - Copper complexes
KW - SOD
KW - SOD-mimics
UR - http://www.scopus.com/inward/record.url?scp=14644400014&partnerID=8YFLogxK
U2 - 10.3109/10715769109145782
DO - 10.3109/10715769109145782
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C2 - 1649084
AN - SCOPUS:14644400014
SN - 1071-5762
VL - 12
SP - 167
EP - 171
JO - Free Radical Research
JF - Free Radical Research
IS - 1
ER -