Resistance characteristics of influenza to amino-adamantyls

Peleg Astrahan; Isaiah T. Arkin

doi:10.1016/j.bbamem.2010.06.018

Resistance characteristics of influenza to amino-adamantyls

Peleg Astrahan
, Isaiah T. Arkin

Department of Biological Chemistry

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

The recent outbreaks of avian flu in Southeast Asia and swine flu in Mexico City painfully exemplify the ability of the influenza virus to rapidly mutate and develop resistance to modern medicines. This review seeks to detail the molecular mechanism by which the influenza virus has obtained resistance to amino-adamantyls, one of only two classes of drugs that combat the flu. Amino-adamantyls target the viral M2 H⁺ channel and have become largely ineffective due to mutations in the transmembrane domain of the protein. Herein we describe these resistance rendering mutations and the compounded effects they have upon the protein's function and resulting virus viability.

Original language	English
Pages (from-to)	547-553
Number of pages	7
Journal	Biochimica et Biophysica Acta - Biomembranes
Volume	1808
Issue number	2
DOIs	https://doi.org/10.1016/j.bbamem.2010.06.018
State	Published - Feb 2011

Bibliographical note

Funding Information:
This work was supported in part by grants from the National Institutes of Health ( R21AI064797 ), the Israeli Science Foundation ( 784/01,1249/05,1581/08 ) and the Horowitz Foundation . I.T.A. is the Arthur Lejwa Professor of Structural Biochemistry at the Hebrew University of Jerusalem. The authors are indebted to members of the Arkin and Gilon Labs for numerous helpful discussions and advice.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Channel blockers
Influenza
M2 channel
Viral resistance

Access to Document

10.1016/j.bbamem.2010.06.018

Cite this

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title = "Resistance characteristics of influenza to amino-adamantyls",

abstract = "The recent outbreaks of avian flu in Southeast Asia and swine flu in Mexico City painfully exemplify the ability of the influenza virus to rapidly mutate and develop resistance to modern medicines. This review seeks to detail the molecular mechanism by which the influenza virus has obtained resistance to amino-adamantyls, one of only two classes of drugs that combat the flu. Amino-adamantyls target the viral M2 H+ channel and have become largely ineffective due to mutations in the transmembrane domain of the protein. Herein we describe these resistance rendering mutations and the compounded effects they have upon the protein's function and resulting virus viability.",

keywords = "Channel blockers, Influenza, M2 channel, Viral resistance",

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AB - The recent outbreaks of avian flu in Southeast Asia and swine flu in Mexico City painfully exemplify the ability of the influenza virus to rapidly mutate and develop resistance to modern medicines. This review seeks to detail the molecular mechanism by which the influenza virus has obtained resistance to amino-adamantyls, one of only two classes of drugs that combat the flu. Amino-adamantyls target the viral M2 H+ channel and have become largely ineffective due to mutations in the transmembrane domain of the protein. Herein we describe these resistance rendering mutations and the compounded effects they have upon the protein's function and resulting virus viability.

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Resistance characteristics of influenza to amino-adamantyls

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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