TY - JOUR
T1 - Resistance of bacterial protein synthesis to double-stranded RNA
AU - Jay, Gilbert
AU - Abrams, William R.
AU - Kaempfer, Raymond
PY - 1974/10/23
Y1 - 1974/10/23
N2 - Double-stranded RNA fails to inhibit the formation of translation initiation complexes on R17 bacteriophage RNA, overall synthesis of R17 proteins, or the ability of bacterial initiation factor IF-3 to prevent the association of 30S and 50S ribosomal subunits into single ribosomes. Yet, IF-3 can form complexes with double-stranded RNA. However, IF-3 binds to double-stranded RNA with lower apparent affinity than to either R17 RNA or 30S ribosomal subunits; this may explain the resistance of bacterial protein synthesis to double-stranded RNA.
AB - Double-stranded RNA fails to inhibit the formation of translation initiation complexes on R17 bacteriophage RNA, overall synthesis of R17 proteins, or the ability of bacterial initiation factor IF-3 to prevent the association of 30S and 50S ribosomal subunits into single ribosomes. Yet, IF-3 can form complexes with double-stranded RNA. However, IF-3 binds to double-stranded RNA with lower apparent affinity than to either R17 RNA or 30S ribosomal subunits; this may explain the resistance of bacterial protein synthesis to double-stranded RNA.
UR - http://www.scopus.com/inward/record.url?scp=0016300153&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(74)90347-7
DO - 10.1016/0006-291X(74)90347-7
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C2 - 4214381
AN - SCOPUS:0016300153
SN - 0006-291X
VL - 60
SP - 1357
EP - 1364
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 4
ER -