Resistance to barbiturate is changed by developmental alteration of dopamine receptor sensitivity

Joseph Yanai; Rachelle H.B. Fishman

doi:10.1016/0736-5748(84)90060-1

Resistance to barbiturate is changed by developmental alteration of dopamine receptor sensitivity

Joseph Yanai^*, Rachelle H.B. Fishman

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Adult rats whose dopamine receptor number was reduced via prenatal haloperidol exposure were less resistant than controls to pentobarbital narcosis. This altered resistance was functional (CNS) and not metabolic, as shown by pentobarbital brain levels. These results are consistent with our previous experiments, indicating that changes in the number of dopamine receptors may underlie relative susceptibility to barbiturates.

Original language	English
Pages (from-to)	61-64
Number of pages	4
Journal	International Journal of Developmental Neuroscience
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/0736-5748(84)90060-1
State	Published - 1984

Keywords

Barbiturate
Brain barbiturate levels
Dopamine receptor number
Haloperidol
Prenatal exposure
Rats
Sleep time

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10.1016/0736-5748(84)90060-1

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abstract = "Adult rats whose dopamine receptor number was reduced via prenatal haloperidol exposure were less resistant than controls to pentobarbital narcosis. This altered resistance was functional (CNS) and not metabolic, as shown by pentobarbital brain levels. These results are consistent with our previous experiments, indicating that changes in the number of dopamine receptors may underlie relative susceptibility to barbiturates.",

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AB - Adult rats whose dopamine receptor number was reduced via prenatal haloperidol exposure were less resistant than controls to pentobarbital narcosis. This altered resistance was functional (CNS) and not metabolic, as shown by pentobarbital brain levels. These results are consistent with our previous experiments, indicating that changes in the number of dopamine receptors may underlie relative susceptibility to barbiturates.

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KW - Brain barbiturate levels

KW - Dopamine receptor number

KW - Haloperidol

KW - Prenatal exposure

KW - Rats

KW - Sleep time

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Resistance to barbiturate is changed by developmental alteration of dopamine receptor sensitivity

Abstract

Keywords

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