Resolvin D1 shows osseous-protection via RANK reduction on monocytes during orthodontic tooth movement

Yehuda Klein, Offir Levin-Talmor, Jaime Garber Berkstein, Sharon Wald, Yaron Meirow, Avi Maimon, Avi Leibovich, Yechezkel Barenholz, David Polak, Stella Chaushu*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    3 Scopus citations

    Abstract

    The study aimed to investigate the role of RvD1 in acute and prolonged sterile inflammation and bone remodeling. A mouse model of sterile inflammation that involves bone resorption was used to examine endogenous RvD1 kinetics during inflammation. Application of exogenous RvD1 significantly inhibited bone remodeling via osteoclast reduction, alongside an anti-inflammatory secretome shift, increased macrophages recruitment and reduction of T-cytotoxic cells. In vitro and in vivo, RvD1 led to significant reduction in RANK expression which reduce osteoclastogenesis in a dose-dependent manner. Taken together, the data shows a dual role for RvD1, as a potent immunoresolvent agent alongside an osteoresolvent role, showing a potential therapeutic agent in bone resorption associated inflammatory conditions.

    Original languageAmerican English
    Article number928132
    JournalFrontiers in Immunology
    Volume13
    DOIs
    StatePublished - 7 Oct 2022

    Bibliographical note

    Publisher Copyright:
    Copyright © 2022 Klein, Levin-Talmor, Berkstein, Wald, Meirow, Maimon, Leibovich, Barenholz, Polak and Chaushu.

    Keywords

    • Resolvin D1
    • Resolvin D1 in orthodontic tooth movement
    • bone remodeling
    • immunomodulation
    • orthodontic tooth movement
    • osteoclastogenesis

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