Response surface methodology in biotechnology

David M. Steinberg, Dizza Bursztyn

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Many experiments in biotechnology exploit the principles and methods of response surface methodology (RSM). The Quality by Design initiative in pharmaceutical development will accelerate this trend. In this article we give a broad picture of the important role played by RSM in biotechnology experimentation. We give brief descriptions of a collection of studies using RSM from recent issues of biotechnology journals, present some of the issues in the design and analysis of experiments for cell media, and look in detail at one of the experiments.

Original languageAmerican English
Pages (from-to)78-87
Number of pages10
JournalQuality Engineering
Issue number2
StatePublished - Apr 2010
Externally publishedYes


  • Design of experiments
  • George Box
  • Industrial experimentation
  • Media optimization
  • QbD
  • Response surface methods


Dive into the research topics of 'Response surface methodology in biotechnology'. Together they form a unique fingerprint.

Cite this