Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”

Neta Shlezinger; Henriette Irmer; Sourabh Dhingra; Sarah R. Beattie; Robert A. Cramer; Gerhard H. Braus; Amir Sharon; Tobias M. Hohl

doi:10.1126/science.aas9457

Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”

Neta Shlezinger, Henriette Irmer, Sourabh Dhingra, Sarah R. Beattie, Robert A. Cramer, Gerhard H. Braus, Amir Sharon, Tobias M. Hohl^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Aouacheria et al. question the interpretation of contemporary assays to monitor programmed cell death with apoptosis-like features (A-PCD) in Aspergillus fumigatus. Although our study focuses on fungal A-PCD for host immune surveillance and infectious outcomes, the experimental approach incorporates multiple independent A-PCD markers and genetic manipulations based on fungal rather than mammalian orthologs to circumvent the limitations associated with any single approach.

Original language	English
Article number	eaas9457
Journal	Science
Volume	360
Issue number	6395
DOIs	https://doi.org/10.1126/science.aas9457
State	Published - 22 Jun 2018
Externally published	Yes

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© 2017 The Authors.

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title = "Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”",

abstract = "Aouacheria et al. question the interpretation of contemporary assays to monitor programmed cell death with apoptosis-like features (A-PCD) in Aspergillus fumigatus. Although our study focuses on fungal A-PCD for host immune surveillance and infectious outcomes, the experimental approach incorporates multiple independent A-PCD markers and genetic manipulations based on fungal rather than mammalian orthologs to circumvent the limitations associated with any single approach.",

author = "Neta Shlezinger and Henriette Irmer and Sourabh Dhingra and Beattie, {Sarah R.} and Cramer, {Robert A.} and Braus, {Gerhard H.} and Amir Sharon and Hohl, {Tobias M.}",

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AU - Beattie, Sarah R.

AU - Cramer, Robert A.

AU - Braus, Gerhard H.

AU - Sharon, Amir

AU - Hohl, Tobias M.

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Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”

Abstract

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