Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”

Neta Shlezinger; Henriette Irmer; Sourabh Dhingra; Sarah R. Beattie; Robert A. Cramer; Gerhard H. Braus; Amir Sharon; Tobias M. Hohl

doi:10.1126/science.aas9457

Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”

Neta Shlezinger
, Henriette Irmer
, Sourabh Dhingra
, Sarah R. Beattie
, Robert A. Cramer
, Gerhard H. Braus
, Amir Sharon
, Tobias M. Hohl^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Aouacheria et al. question the interpretation of contemporary assays to monitor programmed cell death with apoptosis-like features (A-PCD) in Aspergillus fumigatus. Although our study focuses on fungal A-PCD for host immune surveillance and infectious outcomes, the experimental approach incorporates multiple independent A-PCD markers and genetic manipulations based on fungal rather than mammalian orthologs to circumvent the limitations associated with any single approach.

Original language	English
Article number	eaas9457
Journal	Science
Volume	360
Issue number	6395
DOIs	https://doi.org/10.1126/science.aas9457
State	Published - 22 Jun 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 The Authors.

Access to Document

10.1126/science.aas9457

Cite this

@article{caea92264f5241d2a90d4b44538d4ad0,

title = "Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”",

abstract = "Aouacheria et al. question the interpretation of contemporary assays to monitor programmed cell death with apoptosis-like features (A-PCD) in Aspergillus fumigatus. Although our study focuses on fungal A-PCD for host immune surveillance and infectious outcomes, the experimental approach incorporates multiple independent A-PCD markers and genetic manipulations based on fungal rather than mammalian orthologs to circumvent the limitations associated with any single approach.",

author = "Neta Shlezinger and Henriette Irmer and Sourabh Dhingra and Beattie, \{Sarah R.\} and Cramer, \{Robert A.\} and Braus, \{Gerhard H.\} and Amir Sharon and Hohl, \{Tobias M.\}",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors.",

year = "2018",

month = jun,

day = "22",

doi = "10.1126/science.aas9457",

language = "אנגלית",

volume = "360",

journal = "Science",

issn = "0036-8075",

number = "6395",

}

TY - JOUR

T1 - Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”

AU - Shlezinger, Neta

AU - Irmer, Henriette

AU - Dhingra, Sourabh

AU - Beattie, Sarah R.

AU - Cramer, Robert A.

AU - Braus, Gerhard H.

AU - Sharon, Amir

AU - Hohl, Tobias M.

PY - 2018/6/22

Y1 - 2018/6/22

N2 - Aouacheria et al. question the interpretation of contemporary assays to monitor programmed cell death with apoptosis-like features (A-PCD) in Aspergillus fumigatus. Although our study focuses on fungal A-PCD for host immune surveillance and infectious outcomes, the experimental approach incorporates multiple independent A-PCD markers and genetic manipulations based on fungal rather than mammalian orthologs to circumvent the limitations associated with any single approach.

AB - Aouacheria et al. question the interpretation of contemporary assays to monitor programmed cell death with apoptosis-like features (A-PCD) in Aspergillus fumigatus. Although our study focuses on fungal A-PCD for host immune surveillance and infectious outcomes, the experimental approach incorporates multiple independent A-PCD markers and genetic manipulations based on fungal rather than mammalian orthologs to circumvent the limitations associated with any single approach.

UR - https://www.scopus.com/pages/publications/85048977198

U2 - 10.1126/science.aas9457

DO - 10.1126/science.aas9457

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???

C2 - 29930111

AN - SCOPUS:85048977198

SN - 0036-8075

VL - 360

JO - Science

JF - Science

IS - 6395

M1 - eaas9457

ER -

Response to Comment on “Sterilizing immunity in the lung relies on targeting fungal apoptosis-like programmed cell death”

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this