Response, tolerance and ignorance following oral exposure to a single dietary protein antigen in Gallus domesticus

Eyal Klipper, David Sklan, Aharon Friedman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The objective of this investigation was to analyze conditions leading to antibody responses against innocuous dietary protein antigens in the chick. The physical form of antigen was found to be important for immunization of mature chicks: bovine serum albumin (BSA) in solution was a powerful immunogen, while BSA powder was ignored. When BSA was fed to newly hatched chicks, either in solution or as powder, specific oral tolerance was induced. Tolerance increased with the dose of antigen fed, and was most effective in suppressing BSA-specific oral immunization. Hence, immune responses of mature chicks to innocuous dietary proteins are not likely to constitute a health hazard due to (a) prevalence of oral tolerance induced at hatch, and (b) availability of dietary proteins in solid form.

Original languageEnglish
Pages (from-to)2890-2897
Number of pages8
JournalVaccine
Volume19
Issue number20-22
DOIs
StatePublished - 6 Apr 2001

Keywords

  • Chicken
  • Mucosal immunity
  • Oral tolerance

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