Abstract
The objective of this investigation was to analyze conditions leading to antibody responses against innocuous dietary protein antigens in the chick. The physical form of antigen was found to be important for immunization of mature chicks: bovine serum albumin (BSA) in solution was a powerful immunogen, while BSA powder was ignored. When BSA was fed to newly hatched chicks, either in solution or as powder, specific oral tolerance was induced. Tolerance increased with the dose of antigen fed, and was most effective in suppressing BSA-specific oral immunization. Hence, immune responses of mature chicks to innocuous dietary proteins are not likely to constitute a health hazard due to (a) prevalence of oral tolerance induced at hatch, and (b) availability of dietary proteins in solid form.
Original language | English |
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Pages (from-to) | 2890-2897 |
Number of pages | 8 |
Journal | Vaccine |
Volume | 19 |
Issue number | 20-22 |
DOIs | |
State | Published - 6 Apr 2001 |
Keywords
- Chicken
- Mucosal immunity
- Oral tolerance