In contrast to the accepted notion that tumor-derived signals polarize macrophages toward a protumorigenic M2 phenotype during tumor progression, we recently discovered that the inflammatory microenvironment is capable of driving macrophages toward an M2 phenotype. Moreover, our data suggests that inflammatory education is prominent during the early phases of hepatocellular carcinoma (HCC) suggesting that inflammatory modulation might effectively prevent HCC.
Bibliographical noteFunding Information:
Research leading to these results received funding from the European Research Council Grant Agreements 281738 to E.P; the Dr. Miriam and Shel- don G. Adelson Medical Research Foun dation (AMRF); the Israel Science Foundation (ISF) Centers of Excellence (1779/11) to E.P; and ISF individual grant to I.S.
© 2015 Taylor & Francis Group, LLC.
- c-Jun phosphorylation
- hepatocellular carcinoma
- immune check point drugs
- inflammation-induced cancer
- macrophage polarization