Retinoid metabolism in human leucocytes

D. Sklan, S. Trifon, O. Kedar

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Leucocytes from subjects from 0 to 80 years old were separated into mononuclear and granulocyte fractions and the retinoids and retinoid-binding fractions were examined. Both leucocyte fractions were found to contain retinol, retinoic acid and an additional retinoid; retinoic acid comprised 40% of retinoids in some samples. The protein fractions containing retinoids included a 200 kDa protein and several 14–18 kDa proteins. Plasma concentrations of retinol changed little with increasing age. In contrast, leucocyte concentrations of retinoids and retinoid-binding proteins increased quadratically with age. However, in granulocytes from young children retinoids were almost undetectable.

Original languageAmerican English
Pages (from-to)889-895
Number of pages7
JournalBritish Journal of Nutrition
Issue number6
StatePublished - Jun 1995


Dive into the research topics of 'Retinoid metabolism in human leucocytes'. Together they form a unique fingerprint.

Cite this