Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice (Nature Biotechnology, (2014), 32, 1, (76-83), 10.1038/nbt.2747)

Luc Baeyens; Marie Lemper; Gunter Leuckx; Sofie De Groef; Paola Bonfanti; Geert Stangé; Ruth Shemer; Christoffer Nord; David W. Scheel; Fong C. Pan; Ulf Ahlgren; Guoqiang Gu; Doris A. Stoffers; Yuval Dor; Jorge Ferrer; Gerard Gradwohl; Christopher V.E. Wright; Mark Van de Casteele; Michael S. German; Luc Bouwens; Harry Heimberg

doi:10.1038/s41587-020-0426-2

Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice (Nature Biotechnology, (2014), 32, 1, (76-83), 10.1038/nbt.2747)

Luc Baeyens, Marie Lemper, Gunter Leuckx, Sofie De Groef, Paola Bonfanti, Geert Stangé, Ruth Shemer, Christoffer Nord, David W. Scheel, Fong C. Pan, Ulf Ahlgren, Guoqiang Gu, Doris A. Stoffers, Yuval Dor, Jorge Ferrer, Gerard Gradwohl, Christopher V.E. Wright, Mark Van de Casteele, Michael S. German, Luc Bouwens^*Harry Heimberg

^*Corresponding author for this work

Department of Developmental Biology and Cancer Research

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

The authors are retracting this paper owing to errors in the reported data. The paper claimed that treatment with a combination of epidermal growth factor and ciliary neurotrophic factor normalized glycemia and converted acinar cells to beta cells in 65% of hyperglycemic mice studied. However, these findings were not reproduced when the authors recently repeated the experiments. Reexamination by immunohistochemistry and genotyping of archived pancreas tissue samples from mice used in Baeyens et al. showed that the transgenic mice reported in Supplementary Figs. 3 and 6 and in Figs. 4 and 5 were misidentified, invalidating data central to the main claims of the paper.

Original language	English
Pages (from-to)	374
Number of pages	1
Journal	Nature Biotechnology
Volume	38
Issue number	3
DOIs	https://doi.org/10.1038/s41587-020-0426-2
State	Published - 1 Mar 2020

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Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.

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Baeyens, L., Lemper, M., Leuckx, G., De Groef, S., Bonfanti, P., Stangé, G., Shemer, R., Nord, C., Scheel, D. W., Pan, F. C., Ahlgren, U., Gu, G., Stoffers, D. A., Dor, Y., Ferrer, J., Gradwohl, G., Wright, C. V. E., Van de Casteele, M., German, M. S., ... Heimberg, H. (2020). Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice (Nature Biotechnology, (2014), 32, 1, (76-83), 10.1038/nbt.2747). Nature Biotechnology, 38(3), 374. https://doi.org/10.1038/s41587-020-0426-2

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title = "Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice (Nature Biotechnology, (2014), 32, 1, (76-83), 10.1038/nbt.2747)",

abstract = "The authors are retracting this paper owing to errors in the reported data. The paper claimed that treatment with a combination of epidermal growth factor and ciliary neurotrophic factor normalized glycemia and converted acinar cells to beta cells in 65% of hyperglycemic mice studied. However, these findings were not reproduced when the authors recently repeated the experiments. Reexamination by immunohistochemistry and genotyping of archived pancreas tissue samples from mice used in Baeyens et al. showed that the transgenic mice reported in Supplementary Figs. 3 and 6 and in Figs. 4 and 5 were misidentified, invalidating data central to the main claims of the paper.",

author = "Luc Baeyens and Marie Lemper and Gunter Leuckx and {De Groef}, Sofie and Paola Bonfanti and Geert Stang{\'e} and Ruth Shemer and Christoffer Nord and Scheel, {David W.} and Pan, {Fong C.} and Ulf Ahlgren and Guoqiang Gu and Stoffers, {Doris A.} and Yuval Dor and Jorge Ferrer and Gerard Gradwohl and Wright, {Christopher V.E.} and {Van de Casteele}, Mark and German, {Michael S.} and Luc Bouwens and Harry Heimberg",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.",

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doi = "10.1038/s41587-020-0426-2",

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Baeyens, L, Lemper, M, Leuckx, G, De Groef, S, Bonfanti, P, Stangé, G, Shemer, R, Nord, C, Scheel, DW, Pan, FC, Ahlgren, U, Gu, G, Stoffers, DA, Dor, Y, Ferrer, J, Gradwohl, G, Wright, CVE, Van de Casteele, M, German, MS, Bouwens, L & Heimberg, H 2020, 'Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice (Nature Biotechnology, (2014), 32, 1, (76-83), 10.1038/nbt.2747)', Nature Biotechnology, vol. 38, no. 3, pp. 374. https://doi.org/10.1038/s41587-020-0426-2

Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice (Nature Biotechnology, (2014), 32, 1, (76-83), 10.1038/nbt.2747). / Baeyens, Luc; Lemper, Marie; Leuckx, Gunter et al.
In: Nature Biotechnology, Vol. 38, No. 3, 01.03.2020, p. 374.

Research output: Contribution to journal › Comment/debate

TY - JOUR

T1 - Retraction Note

T2 - Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice (Nature Biotechnology, (2014), 32, 1, (76-83), 10.1038/nbt.2747)

AU - Baeyens, Luc

AU - Lemper, Marie

AU - Leuckx, Gunter

AU - De Groef, Sofie

AU - Bonfanti, Paola

AU - Stangé, Geert

AU - Shemer, Ruth

AU - Nord, Christoffer

AU - Scheel, David W.

AU - Pan, Fong C.

AU - Ahlgren, Ulf

AU - Gu, Guoqiang

AU - Stoffers, Doris A.

AU - Dor, Yuval

AU - Ferrer, Jorge

AU - Gradwohl, Gerard

AU - Wright, Christopher V.E.

AU - Van de Casteele, Mark

AU - German, Michael S.

AU - Bouwens, Luc

AU - Heimberg, Harry

PY - 2020/3/1

Y1 - 2020/3/1

N2 - The authors are retracting this paper owing to errors in the reported data. The paper claimed that treatment with a combination of epidermal growth factor and ciliary neurotrophic factor normalized glycemia and converted acinar cells to beta cells in 65% of hyperglycemic mice studied. However, these findings were not reproduced when the authors recently repeated the experiments. Reexamination by immunohistochemistry and genotyping of archived pancreas tissue samples from mice used in Baeyens et al. showed that the transgenic mice reported in Supplementary Figs. 3 and 6 and in Figs. 4 and 5 were misidentified, invalidating data central to the main claims of the paper.

AB - The authors are retracting this paper owing to errors in the reported data. The paper claimed that treatment with a combination of epidermal growth factor and ciliary neurotrophic factor normalized glycemia and converted acinar cells to beta cells in 65% of hyperglycemic mice studied. However, these findings were not reproduced when the authors recently repeated the experiments. Reexamination by immunohistochemistry and genotyping of archived pancreas tissue samples from mice used in Baeyens et al. showed that the transgenic mice reported in Supplementary Figs. 3 and 6 and in Figs. 4 and 5 were misidentified, invalidating data central to the main claims of the paper.

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SN - 1087-0156

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JO - Nature Biotechnology

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Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice (Nature Biotechnology, (2014), 32, 1, (76-83), 10.1038/nbt.2747)

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