Abstract
The Ten-a gene of Drosophila melanogaster encodes several alternative variants of a full length member of the Odz/Tenm protein family. A number of Ten-a mutants created by inexact excisions of a resident P-element insertion are embryonic lethal, but show no pair-rule phenotype. In contrast, these mutants, and deficiencies removing Ten-a, do enhance the segmentation phenotype of a weak allele of the paralog gene odz (or Ten-m) to the odz amorphic phenotype. Germ line clone derived Ten-a- embryos display a pair-rule phenotype which phenocopies that of odz. Post segmentation eye patterning phenotypes of Ten-a mutants establish it as a pleiotropic patterning co-partner of odz.
| Original language | English |
|---|---|
| Pages (from-to) | 911-924 |
| Number of pages | 14 |
| Journal | Mechanisms of Development |
| Volume | 124 |
| Issue number | 11-12 |
| DOIs | |
| State | Published - 2007 |
| Externally published | Yes |
Keywords
- Metamerism
- Odz/Tenm genes
- Segmentation
- Signal transduction