Reversal of the interferon-induced block of protein synthesis by purified preparations of eucaryotic initiation factor 2

Raymond Kaempfer; Ruth Israeli; Haim Rosaeli; Sarah Knoller; Asher Zilberstein; Azriel Schmidt; Michel Revel

doi:10.1016/0042-6822(79)90049-7

Reversal of the interferon-induced block of protein synthesis by purified preparations of eucaryotic initiation factor 2

Raymond Kaempfer^*
, Ruth Israeli
, Haim Rosaeli
, Sarah Knoller
, Asher Zilberstein
, Azriel Schmidt
, Michel Revel

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The translation of Mengo virus RNA in extracts of interferon-treated mouse L cells in the presence of double-stranded RNA is inhibited about 80% when compared to translation in control cell extracts. Addition of eucaryotic initiation factor 2 (eIF-2) purified from rabbit reticulocytes leads to effective reversal of the interferon-induced block. This finding suggests that in interferon-treated cell extracts, inactivation of eIF-2 is a major mechanism of translational control.

Original language	English
Pages (from-to)	170-173
Number of pages	4
Journal	Virology
Volume	99
Issue number	1
DOIs	https://doi.org/10.1016/0042-6822(79)90049-7
State	Published - Nov 1979

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10.1016/0042-6822(79)90049-7

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abstract = "The translation of Mengo virus RNA in extracts of interferon-treated mouse L cells in the presence of double-stranded RNA is inhibited about 80\% when compared to translation in control cell extracts. Addition of eucaryotic initiation factor 2 (eIF-2) purified from rabbit reticulocytes leads to effective reversal of the interferon-induced block. This finding suggests that in interferon-treated cell extracts, inactivation of eIF-2 is a major mechanism of translational control.",

author = "Raymond Kaempfer and Ruth Israeli and Haim Rosaeli and Sarah Knoller and Asher Zilberstein and Azriel Schmidt and Michel Revel",

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AU - Kaempfer, Raymond

AU - Israeli, Ruth

AU - Rosaeli, Haim

AU - Knoller, Sarah

AU - Zilberstein, Asher

AU - Schmidt, Azriel

AU - Revel, Michel

PY - 1979/11

Y1 - 1979/11

N2 - The translation of Mengo virus RNA in extracts of interferon-treated mouse L cells in the presence of double-stranded RNA is inhibited about 80% when compared to translation in control cell extracts. Addition of eucaryotic initiation factor 2 (eIF-2) purified from rabbit reticulocytes leads to effective reversal of the interferon-induced block. This finding suggests that in interferon-treated cell extracts, inactivation of eIF-2 is a major mechanism of translational control.

AB - The translation of Mengo virus RNA in extracts of interferon-treated mouse L cells in the presence of double-stranded RNA is inhibited about 80% when compared to translation in control cell extracts. Addition of eucaryotic initiation factor 2 (eIF-2) purified from rabbit reticulocytes leads to effective reversal of the interferon-induced block. This finding suggests that in interferon-treated cell extracts, inactivation of eIF-2 is a major mechanism of translational control.

UR - https://www.scopus.com/pages/publications/0018611560

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Reversal of the interferon-induced block of protein synthesis by purified preparations of eucaryotic initiation factor 2

Abstract

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