Reversed BCR ABL rearrangement detected by FISH in Philadelphia negative chronic myelocytic leukemia

Dvorah Abeliovich; Orly Yehuda; Svetlana Krichevsky; Arnon Nagler; Susana Ben-Neriah; Marion Werner; Olga Ludkovsky; Dina Ben-Yehuda

doi:10.1016/0165-4608(94)00321-2

Reversed BCR ABL rearrangement detected by FISH in Philadelphia negative chronic myelocytic leukemia

Dvorah Abeliovich
, Orly Yehuda
, Svetlana Krichevsky
, Arnon Nagler
, Susana Ben-Neriah
, Marion Werner
, Olga Ludkovsky
, Dina Ben-Yehuda^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We investigated leukemic cells from a patient with chronic myelocytic leukemia (CML) and a normal 46,XX karyotype. Molecular studies revealed rearrangement of the M-bcr region and formation of BCR ABL fusion mRNA with b3a2 configuration. Fluorescence in situ hybridization (FISH) using the abl probe showed signal on both chromosomes 9 band q34, while the bcr probe hybridized to one chromosome 22 and to one chromosome 9. In this case, as in three other cases recently described (Hagemeijer et al. and Nachava et al.), the bcr abl rearrangement is shown to be on 9q34, instead of the usual location on 22q11.

Original language	English
Pages (from-to)	115-117
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	81
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(94)00321-2
State	Published - Jun 1995
Externally published	Yes

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10.1016/0165-4608(94)00321-2

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title = "Reversed BCR ABL rearrangement detected by FISH in Philadelphia negative chronic myelocytic leukemia",

abstract = "We investigated leukemic cells from a patient with chronic myelocytic leukemia (CML) and a normal 46,XX karyotype. Molecular studies revealed rearrangement of the M-bcr region and formation of BCR ABL fusion mRNA with b3a2 configuration. Fluorescence in situ hybridization (FISH) using the abl probe showed signal on both chromosomes 9 band q34, while the bcr probe hybridized to one chromosome 22 and to one chromosome 9. In this case, as in three other cases recently described (Hagemeijer et al. and Nachava et al.), the bcr abl rearrangement is shown to be on 9q34, instead of the usual location on 22q11.",

author = "Dvorah Abeliovich and Orly Yehuda and Svetlana Krichevsky and Arnon Nagler and Susana Ben-Neriah and Marion Werner and Olga Ludkovsky and Dina Ben-Yehuda",

year = "1995",

month = jun,

doi = "10.1016/0165-4608(94)00321-2",

language = "אנגלית",

volume = "81",

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journal = "Cancer Genetics and Cytogenetics",

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T1 - Reversed BCR ABL rearrangement detected by FISH in Philadelphia negative chronic myelocytic leukemia

AU - Abeliovich, Dvorah

AU - Yehuda, Orly

AU - Krichevsky, Svetlana

AU - Nagler, Arnon

AU - Ben-Neriah, Susana

AU - Werner, Marion

AU - Ludkovsky, Olga

AU - Ben-Yehuda, Dina

PY - 1995/6

Y1 - 1995/6

N2 - We investigated leukemic cells from a patient with chronic myelocytic leukemia (CML) and a normal 46,XX karyotype. Molecular studies revealed rearrangement of the M-bcr region and formation of BCR ABL fusion mRNA with b3a2 configuration. Fluorescence in situ hybridization (FISH) using the abl probe showed signal on both chromosomes 9 band q34, while the bcr probe hybridized to one chromosome 22 and to one chromosome 9. In this case, as in three other cases recently described (Hagemeijer et al. and Nachava et al.), the bcr abl rearrangement is shown to be on 9q34, instead of the usual location on 22q11.

AB - We investigated leukemic cells from a patient with chronic myelocytic leukemia (CML) and a normal 46,XX karyotype. Molecular studies revealed rearrangement of the M-bcr region and formation of BCR ABL fusion mRNA with b3a2 configuration. Fluorescence in situ hybridization (FISH) using the abl probe showed signal on both chromosomes 9 band q34, while the bcr probe hybridized to one chromosome 22 and to one chromosome 9. In this case, as in three other cases recently described (Hagemeijer et al. and Nachava et al.), the bcr abl rearrangement is shown to be on 9q34, instead of the usual location on 22q11.

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DO - 10.1016/0165-4608(94)00321-2

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AN - SCOPUS:0029145347

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VL - 81

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EP - 117

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

Reversed BCR ABL rearrangement detected by FISH in Philadelphia negative chronic myelocytic leukemia

Abstract

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