Reversibility of sodium-induced aggregation of sonicated phosphatidylserine vesicles.

E. P. Day*, A. Y. Kwok, S. K. Hark, J. T. Ho, W. J. Vail, J. Bentz, S. Nir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

The kinetics of sodium-induced aggregation of sonicated phosphatidylserine vesicles has been studied as a function of sodium concentration and temperature. The concentration threshold for aggregation induced by monovalent sodium has been found to be 550 mM sodium by stopped-flow rapid-mixing techniques. This aggregation is completely reversible to changes in sodium ion concentration and to changes in temperature. The aggregation rate decreases with increasing temperature, indicating that the backward reaction rate increases more rapidly with temperature than does the forward rate.

Original languageEnglish
Pages (from-to)4026-4029
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume77
Issue number7
DOIs
StatePublished - Jul 1980

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