Reversible Ag+-crosslinked DNA hydrogels

Weiwei Guo; Xiu Juan Qi; Ron Orbach; Chun Hua Lu; Lina Freage; Iris Mironi-Harpaz; Dror Seliktar; Huang Hao Yang; Itamar Willner

doi:10.1039/c3cc49140d

Reversible Ag⁺-crosslinked DNA hydrogels

Weiwei Guo, Xiu Juan Qi, Ron Orbach, Chun Hua Lu, Lina Freage, Iris Mironi-Harpaz, Dror Seliktar, Huang Hao Yang, Itamar Willner^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

DNA hydrogels, consisting of Y-shaped nucleic acid subunits or of nucleic acid-functionalized acrylamide chains, undergo switchable gel-to-solution transitions. The Ag⁺-stimulated formation of cytosine–Ag⁺–cytosine complexes results in the crosslinking of the units to yield the hydrogels, while the cysteamine-induced elimination of the Ag⁺ ions dissociates the hydrogels into a solution phase.

Original language	English
Pages (from-to)	4065-4068
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	31
DOIs	https://doi.org/10.1039/c3cc49140d
State	Published - 20 Mar 2014

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abstract = "DNA hydrogels, consisting of Y-shaped nucleic acid subunits or of nucleic acid-functionalized acrylamide chains, undergo switchable gel-to-solution transitions. The Ag+-stimulated formation of cytosine–Ag+–cytosine complexes results in the crosslinking of the units to yield the hydrogels, while the cysteamine-induced elimination of the Ag+ ions dissociates the hydrogels into a solution phase.",

author = "Weiwei Guo and Qi, {Xiu Juan} and Ron Orbach and Lu, {Chun Hua} and Lina Freage and Iris Mironi-Harpaz and Dror Seliktar and Yang, {Huang Hao} and Itamar Willner",

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AU - Guo, Weiwei

AU - Qi, Xiu Juan

AU - Orbach, Ron

AU - Lu, Chun Hua

AU - Freage, Lina

AU - Mironi-Harpaz, Iris

AU - Seliktar, Dror

AU - Yang, Huang Hao

AU - Willner, Itamar

PY - 2014/3/20

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AB - DNA hydrogels, consisting of Y-shaped nucleic acid subunits or of nucleic acid-functionalized acrylamide chains, undergo switchable gel-to-solution transitions. The Ag+-stimulated formation of cytosine–Ag+–cytosine complexes results in the crosslinking of the units to yield the hydrogels, while the cysteamine-induced elimination of the Ag+ ions dissociates the hydrogels into a solution phase.

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Reversible Ag⁺-crosslinked DNA hydrogels

Abstract

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