Abstract
The nuclear lamina is located between the inner nuclear membrane and the peripheral chromatin. It is composed of both peripheral and integral membrane proteins, including lamins and lamina-associated protiens. Lamins can interact with one another, with lamina-associated proteins, with nuclear scaffold proteins, and with chromatin. Likewise, most of the lamina- associated proteins are likely to interact directly with chromatin. The nuclear lamina is required for proper cell cycle regulation, chromatin organization, DNA replication, cell differentiation, and apoptosis. Mutations in proteins of the nuclear lamina can disrupt these activities and cause genetic diseases. The structure and assembly of the nuclear lamina proteins and their roles in chromatin organization and cell cycle regulation were recently reviewed. In this review, we discuss the roles of the nuclear lamina in DNA replication and apoptosis and analyze how mutations in nuclear lamina proteins might cause genetic diseases. (C) 2000 Academic Press.
| Original language | English |
|---|---|
| Pages (from-to) | 313-323 |
| Number of pages | 11 |
| Journal | Journal of Structural Biology |
| Volume | 129 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - Apr 2000 |
Bibliographical note
Funding Information:We thank the Israel–U.S.A. Binational Fund (BSF), the Israel Science Foundation (BRF) (to Y.G.), and the W. W. Smith Charitable Trust (to K.L.W.) for their support of this research. We are grateful to Sheona Drummond, Dale Shumaker, and Kenny Lee for critically reading the manuscript.
Keywords
- Apoptosis
- Chromatin
- DNA replication
- Emerin
- LAP1
- LAP2
- LBR
- Man1
- Muscular dystrophy
- Nuclear envelope
- Nuclear lamina
- Otefin
- UNC-84
- YA