Rigid, self-assembled hydrogel composed of a modified aromatic dipeptide

Assaf Mahler*, Meital Reches, Meirav Rechter, Smadar Cohen, Ehud Gazit

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

721 Scopus citations


The formation of a novel self-assembled hydrogel with remarkable mechanical rigidity by a very simple building block, the Fmoc-diphenylalanine peptide was studied. It was found that dissolving the Fmoc-diphenylalanine peptide at a higher concentration in aqueous solution resulted in the formation of a rigid material with macroscopic characteristics of a gel. Transmission electron microscopy was used to gain better insight into the molecular organization of the hydrogel. Small-deformation oscillatory measurements were used to evaluate the viscoelastic behavior of the self-assembled peptide hydrogel from Fmoc-diphenylalanine peptide final concentration on the hydrogel strength. The newly discovered hydrogel was also examined for its biocompatibility to be used as a scaffold in tissue engineering applications.

Original languageAmerican English
Pages (from-to)1365-1370
Number of pages6
JournalAdvanced Materials
Issue number11
StatePublished - 6 Jun 2006
Externally publishedYes


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