Abstract
The innate immune system has numerous signal transduction pathways that lead to the production of type I interferons in response to exposure of cells to external stimuli. One of these pathways comprises RNA polymerase (Pol) III that senses common DNA viruses, such as cytomegalovirus, vaccinia, herpes simplex virus-1 and varicella zoster virus. This polymerase detects and transcribes viral genomic regions to generate AU-rich transcripts that bring to the induction of type I interferons. Remarkably, Pol III is also stimulated by foreign non-viral DNAs and expression of one of its subunits is induced by an RNA virus, the Sindbis virus. Moreover, a protein subunit of RNase P, which is known to associate with Pol III in initiation complexes, is induced by viral infection. Accordingly, alliance of the two tRNA enzymes in innate immunity merits a consideration.
| Original language | American English |
|---|---|
| Pages (from-to) | 1-11 |
| Number of pages | 11 |
| Journal | Transcription |
| Volume | 12 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Jan 2021 |
Bibliographical note
Funding Information:This work was supported by the Israel Science Foundation [1205/17]; Israel Science Foundation [338/19]; United States - Israel Binational Science Foundation [2015/157]. This research is supported by the Israel Science Foundation (grant #338/19) to Alexander Rouvinski and the United States-Israel Binational Science Foundation (#2015/157) and the Israel Science Foundation (grant #1205/17) to Nayef Jarrous.
Funding Information:
This research is supported by the Israel Science Foundation (grant #338/19) to Alexander Rouvinski and the United States-Israel Binational Science Foundation (#2015/157) and the Israel Science Foundation (grant #1205/17) to Nayef Jarrous.
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
Keywords
- DNA virus
- Pol III
- RNA virus
- RNase P
- innate immune system
