RNA synthesis in cultured human placenta

H. Lorberboum, D. Weinstein, H. Galski, N. de Groot, S. Segal, J. Ilan, R. Folman, A. A. Hochberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The in vitro synthesis of RNA in the human placental tissue, incubated in organ culture, was investigated. We followed the synthesis of the poly A(-) and poly A(+) RNA fractions, and investigated the distribution of the newly synthesized RNA among the subcellular fractions isolated from first and third trimester placentas. The poly A(-) RNA was the major fraction of the RNA synthesized in vitro. The incorporation of [3H]uridine into the poly A(+) RNA fraction was very low. As protein synthesis occurred during the entire incubation period, we suggest the presence of a pool of mRNA molecules in the form of mRNP particles.

Original languageAmerican English
Pages (from-to)103-110
Number of pages8
JournalMolecular Biology Reports
Issue number2
StatePublished - Mar 1982


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