Abstract
Infusion reactions (IRs) are complex, immune-mediated side effects that mainly occur within minutes to hours of receiving a therapeutic dose of intravenously administered pharmaceutical products. These products are diverse and include both traditional pharmaceuticals (for example biological agents and small molecules) and new ones (for example nanotechnology-based products). Although IRs are not unique to nanomedicines, they represent a hurdle for the translation of nanotechnology-based drug products. This Perspective offers a big picture of the pharmaceutical field and examines current understanding of mechanisms responsible for IRs to nanomedicines. We outline outstanding questions, review currently available experimental evidence to provide some answers and highlight the gaps. We review advantages and limitations of the in vitro tests and animal models used for studying IRs to nanomedicines. Finally, we propose a roadmap to improve current understanding, and we recommend a strategy for overcoming the problem.
| Original language | English |
|---|---|
| Pages (from-to) | 1100-1108 |
| Number of pages | 9 |
| Journal | Nature Nanotechnology |
| Volume | 13 |
| Issue number | 12 |
| DOIs | |
| State | Published - 1 Dec 2018 |
Bibliographical note
Publisher Copyright:© 2018, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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