Role for LDL in estradiol-synthesis capacity of bovine ovarian follicles

N. Argov*, D. Sklan, A. Arieli

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The steroidogenic capacity of several tissues has been shown to be regulated by lipoproteins. However, the ability of the various lipoprotein classes to affect steroid production in general and estradiol-synthesis in particular has not been established in bovine ovarian cells. In previous studies, we described alterations in the lipoprotein profiles in follicles of different sizes and corresponding changes in lipoprotein-receptor gene expression. In the present study, the effect of low-density lipoprotein (LDL)-enriched medium on aromatization competence of whole ovarian follicles was determined in vitro. Gene expression of aromatase increased and that of selective-uptake receptors decreased in the presence of LDL. These results suggest a role for LDL availability in folliculogenesis.

Original languageAmerican English
Pages (from-to)289-293
Number of pages5
JournalLivestock Science
Issue number2-3
StatePublished - Apr 2007


  • Aromatase
  • Lipoprotein
  • Ovarian follicle


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