Role of adrenergic neurone blockade in the hypotensive action of propranolol

SARAH ELIASH*, MARTA WEINSTOCK

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Propranolol, in doses of 25–100 μg/kg, blocks contractions of the nictitating membrane to nerve stimulation but not to injected noradrenaline. This adrenergic neurone blocking action of propranolol is antagonized by amphetamine. It is also reversed by raising the dose of propranolol to amounts exceeding 0·5 mg/kg. Still larger amounts potentiate the responses of the nictitating membrane to both submaximal stimulation of the cervical sympathetic nerve and to injected noradrenaline. The (+) isomer of propranolol produced adrenergic nerve blockade and some degree of hypotension without blocking cardiac β‐adrenoceptors. The relevance of adrenergic neurone blockade to the hypotensive effect of propranolol is discussed. 1971 British Pharmacological Society

Original languageEnglish
Pages (from-to)287-294
Number of pages8
JournalBritish Journal of Pharmacology
Volume43
Issue number2
DOIs
StatePublished - Oct 1971
Externally publishedYes

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