Role of Arachidonic Acid in Collagenase IV Production and Malignant Behavior of Tumor Cells

R. Reich; L. Royce; S. H. Adler; G. R. Martin; R. A. Partis; R. A. Mueller

doi:10.1007/978-1-4615-3874-5_56

Role of Arachidonic Acid in Collagenase IV Production and Malignant Behavior of Tumor Cells

R. Reich
, L. Royce
, S. H. Adler
, G. R. Martin
, R. A. Partis
, R. A. Mueller

School of Pharmacy

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The spread of cancer from the original lesion is a critical event in cancer etiology, placing the tumor beyond conventional modes of treatment. Indeed, metastasis is the major cause of death in cancer (1). The actual success of a given tumor cell to metastasize depends on numerous factors including the invasiveness of the tumor cell, the host’s immune system and local factors which support the growth of the tumor at different sites (2–4). During metastasis the cells must breach numerous barriers to their invasion and dissemination. These barriers include stromal matrix, basement membranes and cellular layers. Because of the diversity of these barriers, the penetration of the cells must involve proteolytic enzymes.

Original language	American English
Title of host publication	Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury: Proceedings of the 1st International Conference October 11–14, 1989 Detroit, Michigan USA
Editors	Kenneth V. Honn, Lawrence J. Marnett, Santosh Nigam, Thomas L. Walden
Place of Publication	Boston, MA
Publisher	Springer US; Imprint: Springer
Pages	379-383
Number of pages	5
ISBN (Print)	978-1-4615-3874-5
DOIs	https://doi.org/10.1007/978-1-4615-3874-5_56
State	Published - 1991

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10.1007/978-1-4615-3874-5_56

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Reich, R., Royce, L., Adler, S. H., Martin, G. R., Partis, R. A., & Mueller, R. A. (1991). Role of Arachidonic Acid in Collagenase IV Production and Malignant Behavior of Tumor Cells. In K. V. Honn, L. J. Marnett, S. Nigam, & T. L. Walden (Eds.), Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury: Proceedings of the 1st International Conference October 11–14, 1989 Detroit, Michigan USA (pp. 379-383). Springer US; Imprint: Springer. https://doi.org/10.1007/978-1-4615-3874-5_56

Reich, R. ; Royce, L. ; Adler, S. H. et al. / Role of Arachidonic Acid in Collagenase IV Production and Malignant Behavior of Tumor Cells. Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury: Proceedings of the 1st International Conference October 11–14, 1989 Detroit, Michigan USA. editor / Kenneth V. Honn ; Lawrence J. Marnett ; Santosh Nigam ; Thomas L. Walden. Boston, MA : Springer US; Imprint: Springer, 1991. pp. 379-383

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abstract = "The spread of cancer from the original lesion is a critical event in cancer etiology, placing the tumor beyond conventional modes of treatment. Indeed, metastasis is the major cause of death in cancer (1). The actual success of a given tumor cell to metastasize depends on numerous factors including the invasiveness of the tumor cell, the host{\textquoteright}s immune system and local factors which support the growth of the tumor at different sites (2–4). During metastasis the cells must breach numerous barriers to their invasion and dissemination. These barriers include stromal matrix, basement membranes and cellular layers. Because of the diversity of these barriers, the penetration of the cells must involve proteolytic enzymes.",

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Reich, R, Royce, L, Adler, SH, Martin, GR, Partis, RA & Mueller, RA 1991, Role of Arachidonic Acid in Collagenase IV Production and Malignant Behavior of Tumor Cells. in KV Honn, LJ Marnett, S Nigam & TL Walden (eds), Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury: Proceedings of the 1st International Conference October 11–14, 1989 Detroit, Michigan USA. Springer US; Imprint: Springer, Boston, MA, pp. 379-383. https://doi.org/10.1007/978-1-4615-3874-5_56

Role of Arachidonic Acid in Collagenase IV Production and Malignant Behavior of Tumor Cells. / Reich, R.; Royce, L.; Adler, S. H. et al.
Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury: Proceedings of the 1st International Conference October 11–14, 1989 Detroit, Michigan USA. ed. / Kenneth V. Honn; Lawrence J. Marnett; Santosh Nigam; Thomas L. Walden. Boston, MA: Springer US; Imprint: Springer, 1991. p. 379-383.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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T1 - Role of Arachidonic Acid in Collagenase IV Production and Malignant Behavior of Tumor Cells

AU - Reich, R.

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AU - Martin, G. R.

AU - Partis, R. A.

AU - Mueller, R. A.

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N2 - The spread of cancer from the original lesion is a critical event in cancer etiology, placing the tumor beyond conventional modes of treatment. Indeed, metastasis is the major cause of death in cancer (1). The actual success of a given tumor cell to metastasize depends on numerous factors including the invasiveness of the tumor cell, the host’s immune system and local factors which support the growth of the tumor at different sites (2–4). During metastasis the cells must breach numerous barriers to their invasion and dissemination. These barriers include stromal matrix, basement membranes and cellular layers. Because of the diversity of these barriers, the penetration of the cells must involve proteolytic enzymes.

AB - The spread of cancer from the original lesion is a critical event in cancer etiology, placing the tumor beyond conventional modes of treatment. Indeed, metastasis is the major cause of death in cancer (1). The actual success of a given tumor cell to metastasize depends on numerous factors including the invasiveness of the tumor cell, the host’s immune system and local factors which support the growth of the tumor at different sites (2–4). During metastasis the cells must breach numerous barriers to their invasion and dissemination. These barriers include stromal matrix, basement membranes and cellular layers. Because of the diversity of these barriers, the penetration of the cells must involve proteolytic enzymes.

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M3 - Chapter

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EP - 383

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Reich R, Royce L, Adler SH, Martin GR, Partis RA, Mueller RA. Role of Arachidonic Acid in Collagenase IV Production and Malignant Behavior of Tumor Cells. In Honn KV, Marnett LJ, Nigam S, Walden TL, editors, Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury: Proceedings of the 1st International Conference October 11–14, 1989 Detroit, Michigan USA. Boston, MA: Springer US; Imprint: Springer. 1991. p. 379-383 doi: 10.1007/978-1-4615-3874-5_56

Role of Arachidonic Acid in Collagenase IV Production and Malignant Behavior of Tumor Cells

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