TY - JOUR
T1 - Role of caspase-8 in hepatocyte response to infection and injury in mice
AU - Ben Moshe, Tehila
AU - Barash, Hila
AU - Kang, Tae Bong
AU - Kim, Jin Chul
AU - Kovalenko, Andrew
AU - Gross, Eitan
AU - Schuchmann, Marcus
AU - Abramovitch, Rinat
AU - Galun, Eithan
AU - Wallach, David
PY - 2007/4
Y1 - 2007/4
N2 - Caspase-8 has been implicated in signaling for apoptotic cell death and for certain nonapoptotic functions. However, knowledge of actual physiological or pathophysiological processes to which this enzyme contributes is lacking. Using a mouse model and employing the conditional knockout approach to delete the caspase-8 gene specifically in the liver, we found that caspase-8 deficiency in hepatocytes facilitates infection of the liver by Listeria monocytogenes, attenuates the hepatocyte proliferation wave during the first 48 hours after partial hepatectomy and, depending on the genetic background of the mice, prompts a chronic inflammatory response to the hepatectomy, as a result of which the proliferation of hepatocytes, although initially suppressed, might later be persistently enhanced, resulting in significant hepatomegaly. Conclusion: These findings indicate that caspase-8 participates in regulation of the cellular response to infection and injury and that it does so by affecting various cellular functions, including cell death, cell proliferation, and induction of inflammation.
AB - Caspase-8 has been implicated in signaling for apoptotic cell death and for certain nonapoptotic functions. However, knowledge of actual physiological or pathophysiological processes to which this enzyme contributes is lacking. Using a mouse model and employing the conditional knockout approach to delete the caspase-8 gene specifically in the liver, we found that caspase-8 deficiency in hepatocytes facilitates infection of the liver by Listeria monocytogenes, attenuates the hepatocyte proliferation wave during the first 48 hours after partial hepatectomy and, depending on the genetic background of the mice, prompts a chronic inflammatory response to the hepatectomy, as a result of which the proliferation of hepatocytes, although initially suppressed, might later be persistently enhanced, resulting in significant hepatomegaly. Conclusion: These findings indicate that caspase-8 participates in regulation of the cellular response to infection and injury and that it does so by affecting various cellular functions, including cell death, cell proliferation, and induction of inflammation.
UR - http://www.scopus.com/inward/record.url?scp=34247361535&partnerID=8YFLogxK
U2 - 10.1002/hep.21495
DO - 10.1002/hep.21495
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C2 - 17385212
AN - SCOPUS:34247361535
SN - 0270-9139
VL - 45
SP - 1014
EP - 1024
JO - Hepatology
JF - Hepatology
IS - 4
ER -