Abstract
The ability of different CD4+ T cell subsets to help CD8+ T-cell response is not fully understood. Here, we found using the murine system that Th17 cells induced by IL-1β, unlike Th1, were not effective helpers for antiviral CD8 responses as measured by IFNγ-producing cells or protection against virus infection. However, they skewed CD8 responses to a Tc17 phenotype. Thus, the apparent lack of help was actually immune deviation. This skewing depended on both IL-21 and IL-23. To overcome this effect, we inhibited Th17 induction by blocking TGF-β. Anti-TGF-β allowed the IL-1β adjuvant to enhance CD8+ T-cell responses without skewing the phenotype to Tc17, thereby providing an approach to harness the benefit of common IL-1-inducing adjuvants like alum without immune deviation.
Original language | English |
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Pages (from-to) | 2059-2069 |
Number of pages | 11 |
Journal | European Journal of Immunology |
Volume | 47 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2017 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Keywords
- IFN-γ
- IL-1
- Immune deviation
- Tc17
- TGF-β
- Th1
- Th17