Role of CD4 T cell helper subsets in immune response and deviation of CD8 T cells in mice*

Alison Hogg, Yongjun Sui*, Shlomo Z. Ben-Sasson, William E. Paul, Jay A. Berzofsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The ability of different CD4+ T cell subsets to help CD8+ T-cell response is not fully understood. Here, we found using the murine system that Th17 cells induced by IL-1β, unlike Th1, were not effective helpers for antiviral CD8 responses as measured by IFNγ-producing cells or protection against virus infection. However, they skewed CD8 responses to a Tc17 phenotype. Thus, the apparent lack of help was actually immune deviation. This skewing depended on both IL-21 and IL-23. To overcome this effect, we inhibited Th17 induction by blocking TGF-β. Anti-TGF-β allowed the IL-1β adjuvant to enhance CD8+ T-cell responses without skewing the phenotype to Tc17, thereby providing an approach to harness the benefit of common IL-1-inducing adjuvants like alum without immune deviation.

Original languageEnglish
Pages (from-to)2059-2069
Number of pages11
JournalEuropean Journal of Immunology
Volume47
Issue number12
DOIs
StatePublished - Dec 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • IFN-γ
  • IL-1
  • Immune deviation
  • Tc17
  • TGF-β
  • Th1
  • Th17

Fingerprint

Dive into the research topics of 'Role of CD4 T cell helper subsets in immune response and deviation of CD8 T cells in mice*'. Together they form a unique fingerprint.

Cite this