Role of DNA methylation in the regulation of transcription

Sharon Eden*, Howard Cedar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

291 Scopus citations

Abstract

DNA methylation plays an important role in the regulation of gene expression during development. Methyl moieties at CpG residues suppress transcription by affecting DNA-protein interactions, thus altering the accessibility of genes to trans-acting factors in the cell. Because it works in cis, this mechanism is important in the control of X inactivation and genomic imprinting.

Original languageAmerican English
Pages (from-to)255-259
Number of pages5
JournalCurrent Opinion in Genetics and Development
Volume4
Issue number2
DOIs
StatePublished - Apr 1994

Bibliographical note

Funding Information:
We thank the NIH, the Israel Cancer Research Fund, the Tobacco Research Council, and the US-Israel Binational Science Foundation for their continued support.

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