Role of DNA methylation in the regulation of transcription

Sharon Eden; Howard Cedar

doi:10.1016/S0959-437X(05)80052-8

Role of DNA methylation in the regulation of transcription

Sharon Eden^*, Howard Cedar

^*Corresponding author for this work

Department of Microbiology and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

294 Scopus citations

Abstract

DNA methylation plays an important role in the regulation of gene expression during development. Methyl moieties at CpG residues suppress transcription by affecting DNA-protein interactions, thus altering the accessibility of genes to trans-acting factors in the cell. Because it works in cis, this mechanism is important in the control of X inactivation and genomic imprinting.

Original language	English
Pages (from-to)	255-259
Number of pages	5
Journal	Current Opinion in Genetics and Development
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/S0959-437X(05)80052-8
State	Published - Apr 1994

Bibliographical note

Funding Information:
We thank the NIH, the Israel Cancer Research Fund, the Tobacco Research Council, and the US-Israel Binational Science Foundation for their continued support.

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10.1016/S0959-437X(05)80052-8

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title = "Role of DNA methylation in the regulation of transcription",

abstract = "DNA methylation plays an important role in the regulation of gene expression during development. Methyl moieties at CpG residues suppress transcription by affecting DNA-protein interactions, thus altering the accessibility of genes to trans-acting factors in the cell. Because it works in cis, this mechanism is important in the control of X inactivation and genomic imprinting.",

author = "Sharon Eden and Howard Cedar",

note = "Funding Information: We thank the NIH, the Israel Cancer Research Fund, the Tobacco Research Council, and the US-Israel Binational Science Foundation for their continued support.",

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Role of DNA methylation in the regulation of transcription

Abstract

Bibliographical note

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