Role of HLA-G in Viral Infections

Simon Jasinski-Bergner, Dominik Schmiedel, Ofer Mandelboim, Barbara Seliger*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


The human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule, which has distinct features to classical HLA-A, -B, -C antigens, such as a low polymorphism, different splice variants, highly restricted, tightly regulated expression and immune modulatory properties. HLA-G expression in tumor cells and virus-infected cells, as well as the release of soluble HLA-G leads to escape from host immune surveillance. Increased knowledge of the link between HLA-G expression, viral infection and disease progression is urgently required, which highlights the possible use of HLA-G as novel diagnostic and prognostic biomarker for viral infections, but also as therapeutic target. Therefore, this review aims to summarize the expression, regulation, function and impact of HLA-G in the context of different viral infections including virus-associated cancers. The characterization of HLA-G-driven immune escape mechanisms involved in the interactions between host cells and viruses might result in the design of novel immunotherapeutic strategies targeting HLA-G and/or its interaction with its receptors on immune effector cells.

Original languageAmerican English
Article number826074
JournalFrontiers in Immunology
StatePublished - 14 Feb 2022

Bibliographical note

Publisher Copyright:
Copyright © 2022 Jasinski-Bergner, Schmiedel, Mandelboim and Seliger.


  • human leukocyte antigen G
  • immune escape
  • interleukin 10
  • viral infection
  • virus-induced tumors


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