Role of reactive oxygen species (ROS) in apoptosis induction

H. U. Simon*, A. Haj-Yehia, F. Levi-Schaffer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2455 Scopus citations

Abstract

Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.

Original languageAmerican English
Pages (from-to)415-418
Number of pages4
JournalApoptosis : an international journal on programmed cell death
Volume5
Issue number5
DOIs
StatePublished - 2000

Bibliographical note

Funding Information:
Work of the laboratory of H.U.S. is supported by the Swiss National Science Foundation (31-58916.99), the EMDO Foundation Zurich. Foundation Novartis Basel Helmut Horten Foundation Madonna del Piano, and Stiftung Zur Krebsbekämpting Zürich.

Keywords

  • Apoptosis
  • Death receptors
  • Inflammation
  • Reactive oxygen species (ROS)

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