TY - JOUR
T1 - Role of synchronous release of sodium decanoate on sulpiride absorption in the intestine of the rat
AU - Rubinstein, Abraham
AU - Baluom, Muhammad
AU - Friedman, Michael
PY - 1999/3
Y1 - 1999/3
N2 - The use of absorption enhancers to increase drug bioavailability after oral administration was demonstrated. Sodium decanoate was employed for the enhancement of drug absorption following rectal administration. The non-synchronous formulations were significantly inferior to the synchronous ones in terms of the absorption enhancement of sulpiride. The extent and duration of the enhancement SD effect could be fine-tuned by manipulating the amounts of Hydroxypropyl methylcellulose in the synchronous oral formulations.
AB - The use of absorption enhancers to increase drug bioavailability after oral administration was demonstrated. Sodium decanoate was employed for the enhancement of drug absorption following rectal administration. The non-synchronous formulations were significantly inferior to the synchronous ones in terms of the absorption enhancement of sulpiride. The extent and duration of the enhancement SD effect could be fine-tuned by manipulating the amounts of Hydroxypropyl methylcellulose in the synchronous oral formulations.
UR - http://www.scopus.com/inward/record.url?scp=0033095155&partnerID=8YFLogxK
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AN - SCOPUS:0033095155
SN - 0032-3934
VL - 40
SP - 263
EP - 264
JO - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
JF - American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
IS - 1
T2 - Proceedings of the 1999 ACS Anaheim Meeting
Y2 - 21 March 1999 through 25 March 1999
ER -