TY - JOUR
T1 - Roles of eosinophils in the modulation of angiogenesis
AU - Efraim, Alon H.Nissim Ben
AU - Levi-Schaffer, Francesca
N1 - Publisher Copyright:
© 2014 S. Karger AG, Basel.
PY - 2014
Y1 - 2014
N2 - Chronic allergic inflammatory diseases are characterized by tissue damage with consequent remodeling including fibrosis and angiogenesis. Eosinophils are usually recruited to sites of allergic inflammation infiltrating the tissues as fully differentiated cells. In the last two decades, these cells have been characterized as a proangiogenic. The inadequate blood supply together with a high consumption of oxygen by the infiltrated cells is the main cause of tissue hypoxia in inflammation. Infiltrated eosinophils respond to hypoxia by increasing their viability and proangiogenic potential and regulate the expression of receptors particularly CD300a.
AB - Chronic allergic inflammatory diseases are characterized by tissue damage with consequent remodeling including fibrosis and angiogenesis. Eosinophils are usually recruited to sites of allergic inflammation infiltrating the tissues as fully differentiated cells. In the last two decades, these cells have been characterized as a proangiogenic. The inadequate blood supply together with a high consumption of oxygen by the infiltrated cells is the main cause of tissue hypoxia in inflammation. Infiltrated eosinophils respond to hypoxia by increasing their viability and proangiogenic potential and regulate the expression of receptors particularly CD300a.
UR - http://www.scopus.com/inward/record.url?scp=84904226645&partnerID=8YFLogxK
U2 - 10.1159/000353251
DO - 10.1159/000353251
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C2 - 24217607
AN - SCOPUS:84904226645
SN - 1660-2242
VL - 99
SP - 138
EP - 154
JO - Chemical Immunology and Allergy
JF - Chemical Immunology and Allergy
ER -
