Roles of eosinophils in the modulation of angiogenesis

Alon H.Nissim Ben Efraim, Francesca Levi-Schaffer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Chronic allergic inflammatory diseases are characterized by tissue damage with consequent remodeling including fibrosis and angiogenesis. Eosinophils are usually recruited to sites of allergic inflammation infiltrating the tissues as fully differentiated cells. In the last two decades, these cells have been characterized as a proangiogenic. The inadequate blood supply together with a high consumption of oxygen by the infiltrated cells is the main cause of tissue hypoxia in inflammation. Infiltrated eosinophils respond to hypoxia by increasing their viability and proangiogenic potential and regulate the expression of receptors particularly CD300a.

Original languageAmerican English
Pages (from-to)138-154
Number of pages17
JournalChemical Immunology and Allergy
Volume99
DOIs
StatePublished - 2014

Bibliographical note

Publisher Copyright:
© 2014 S. Karger AG, Basel.

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