Saccharin induces changes in adenylate cyclase activity in liver and muscle membranes in rats

Benjamin J. Striem, Michael Naim*, Uri Zehavi, Tal Ronen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The non-nutritive sweetener, saccharin, was found to stimulate significantly the activity of adenylate cyclase in membranes derived from skeletal muscle of rat. Sodium saccharin enhanced adenylate cyclase activity in a doserelated manner, and this activation appeared to be dependent on the presence of guanine nucleotides, suggesting the involvement of GTP-binding proteins. In membranes derived from the liver, however, sodium saccharin had an effect which was dependent on the concentration of membranes used in the adenylate cyclase assay. In high concentrations of membranes, sodium saccharin had a stimulatory effect, while in low concentration an inhibition was observed.

Original languageEnglish
Pages (from-to)803-810
Number of pages8
JournalLife Sciences
Volume46
Issue number11
DOIs
StatePublished - 1990

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