TY - JOUR
T1 - Saccharin induces changes in adenylate cyclase activity in liver and muscle membranes in rats
AU - Striem, Benjamin J.
AU - Naim, Michael
AU - Zehavi, Uri
AU - Ronen, Tal
PY - 1990
Y1 - 1990
N2 - The non-nutritive sweetener, saccharin, was found to stimulate significantly the activity of adenylate cyclase in membranes derived from skeletal muscle of rat. Sodium saccharin enhanced adenylate cyclase activity in a doserelated manner, and this activation appeared to be dependent on the presence of guanine nucleotides, suggesting the involvement of GTP-binding proteins. In membranes derived from the liver, however, sodium saccharin had an effect which was dependent on the concentration of membranes used in the adenylate cyclase assay. In high concentrations of membranes, sodium saccharin had a stimulatory effect, while in low concentration an inhibition was observed.
AB - The non-nutritive sweetener, saccharin, was found to stimulate significantly the activity of adenylate cyclase in membranes derived from skeletal muscle of rat. Sodium saccharin enhanced adenylate cyclase activity in a doserelated manner, and this activation appeared to be dependent on the presence of guanine nucleotides, suggesting the involvement of GTP-binding proteins. In membranes derived from the liver, however, sodium saccharin had an effect which was dependent on the concentration of membranes used in the adenylate cyclase assay. In high concentrations of membranes, sodium saccharin had a stimulatory effect, while in low concentration an inhibition was observed.
UR - http://www.scopus.com/inward/record.url?scp=0025248162&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(90)90068-3
DO - 10.1016/0024-3205(90)90068-3
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C2 - 2319908
AN - SCOPUS:0025248162
SN - 0024-3205
VL - 46
SP - 803
EP - 810
JO - Life Sciences
JF - Life Sciences
IS - 11
ER -