Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction

Dan Haberman; Rodrigo Estévez-Loureiro; Tomas Benito-Gonzalez; Paolo Denti; Dabit Arzamendi; Marianna Adamo; Xavier Freixa; Luis Nombela-Franco; Pedro Villablanca; Lian Krivoshei; Neil Fam; Konstantinos Spargias; Andrew Czarnecki; Isaac Pascual; Fabien Praz; Doron Sudarsky; Arthur Kerner; Vlasis Ninios; Marco Gennari; Ronen Beeri; Leor Perl; Haim Danenberg; Lion Poles; Sara Shimoni; Sorel Goland; Berenice Caneiro-Queija; Salvatore Scianna; Igal Moaraf; Davide Schiavi; Claudia Scardino; Noé Corpataux; Julio Echarte-Morales; Michael Chrissoheris; Estefanía Fernández-Peregrina; Mattia Di Pasquale; Ander Regueiro; Carlos Vergara-Uzcategui; Andres Iñiguez-Romo; Felipe Fernández-Vázquez; Danny Dvir; Maurizio Taramasso; Mony Shuvy

doi:10.3390/jcm10091819

Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction

Dan Haberman^*, Rodrigo Estévez-Loureiro, Tomas Benito-Gonzalez, Paolo Denti, Dabit Arzamendi, Marianna Adamo, Xavier Freixa, Luis Nombela-Franco, Pedro Villablanca, Lian Krivoshei, Neil Fam, Konstantinos Spargias, Andrew Czarnecki, Isaac Pascual, Fabien Praz, Doron Sudarsky, Arthur Kerner, Vlasis Ninios, Marco Gennari, Ronen BeeriLeor Perl, Haim Danenberg, Lion Poles, Sara Shimoni, Sorel Goland, Berenice Caneiro-Queija, Salvatore Scianna, Igal Moaraf, Davide Schiavi, Claudia Scardino, Noé Corpataux, Julio Echarte-Morales, Michael Chrissoheris, Estefanía Fernández-Peregrina, Mattia Di Pasquale, Ander Regueiro, Carlos Vergara-Uzcategui, Andres Iñiguez-Romo, Felipe Fernández-Vázquez, Danny Dvir, Maurizio Taramasso, Mony Shuvy

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Patients with severe mitral regurgitation (MR) after myocardial infarction (MI) have an increased risk of mortality. Transcatheter mitral valve repair may therefore be a suitable therapy. However, data on clinical outcomes of patients in an acute setting are scarce, especially those with reduced left ventricle (LV) dysfunction. We conducted a multinational, collaborative data analysis from 21 centers for patients who were, within 90 days of acute MI, treated with MitraClip due to severe MR. The cohort was divided according to median left ventricle ejection fraction (LVEF)—35%. Included in the study were 105 patients. The mean age was 71 ± 10 years. Patients in the LVEF < 35% group were younger but with comparable Euroscore II, multivessel coronary artery disease, prior MI and coronary artery bypass graft surgery. Procedure time was comparable and acute success rate was high in both groups (94% vs. 90%, p = 0.728). MR grade was significantly reduced in both groups along with an immediate reduction in left atrial V-wave, pulmonary artery pressure and improvement in New York Heart Association (NYHA) class. In-hospital and 1-year mortality rates were not significantly different between the two groups (11% vs. 7%, p = 0.51 and 19% vs. 12%, p = 0.49) and neither was the 3-month re-hospitalization rate. In conclusion, MitraClip intervention in patients with acute severe functional mitral regurgitation (FMR) due to a recent MI in an acute setting is safe and feasible. Even patients with severe LV dysfunction may benefit from transcatheter mitral valve intervention and should not be excluded.

Original language	English
Article number	1819
Journal	Journal of Clinical Medicine
Volume	10
Issue number	9
DOIs	https://doi.org/10.3390/jcm10091819
State	Published - 22 Apr 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Acute myocardial infarction
Left ventricle dysfunction
Mitral regurgitation
Percutaneous mitral valve repair

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/jcm10091819

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Haberman, D., Estévez-Loureiro, R., Benito-Gonzalez, T., Denti, P., Arzamendi, D., Adamo, M., Freixa, X., Nombela-Franco, L., Villablanca, P., Krivoshei, L., Fam, N., Spargias, K., Czarnecki, A., Pascual, I., Praz, F., Sudarsky, D., Kerner, A., Ninios, V., Gennari, M., ... Shuvy, M. (2021). Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction. Journal of Clinical Medicine, 10(9), Article 1819. https://doi.org/10.3390/jcm10091819

@article{b063d88f9d7c4c379ae9ca02cd60a16c,

title = "Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction",

abstract = "Patients with severe mitral regurgitation (MR) after myocardial infarction (MI) have an increased risk of mortality. Transcatheter mitral valve repair may therefore be a suitable therapy. However, data on clinical outcomes of patients in an acute setting are scarce, especially those with reduced left ventricle (LV) dysfunction. We conducted a multinational, collaborative data analysis from 21 centers for patients who were, within 90 days of acute MI, treated with MitraClip due to severe MR. The cohort was divided according to median left ventricle ejection fraction (LVEF)—35%. Included in the study were 105 patients. The mean age was 71 ± 10 years. Patients in the LVEF < 35% group were younger but with comparable Euroscore II, multivessel coronary artery disease, prior MI and coronary artery bypass graft surgery. Procedure time was comparable and acute success rate was high in both groups (94% vs. 90%, p = 0.728). MR grade was significantly reduced in both groups along with an immediate reduction in left atrial V-wave, pulmonary artery pressure and improvement in New York Heart Association (NYHA) class. In-hospital and 1-year mortality rates were not significantly different between the two groups (11% vs. 7%, p = 0.51 and 19% vs. 12%, p = 0.49) and neither was the 3-month re-hospitalization rate. In conclusion, MitraClip intervention in patients with acute severe functional mitral regurgitation (FMR) due to a recent MI in an acute setting is safe and feasible. Even patients with severe LV dysfunction may benefit from transcatheter mitral valve intervention and should not be excluded.",

keywords = "Acute myocardial infarction, Left ventricle dysfunction, Mitral regurgitation, Percutaneous mitral valve repair",

author = "Dan Haberman and Rodrigo Est{\'e}vez-Loureiro and Tomas Benito-Gonzalez and Paolo Denti and Dabit Arzamendi and Marianna Adamo and Xavier Freixa and Luis Nombela-Franco and Pedro Villablanca and Lian Krivoshei and Neil Fam and Konstantinos Spargias and Andrew Czarnecki and Isaac Pascual and Fabien Praz and Doron Sudarsky and Arthur Kerner and Vlasis Ninios and Marco Gennari and Ronen Beeri and Leor Perl and Haim Danenberg and Lion Poles and Sara Shimoni and Sorel Goland and Berenice Caneiro-Queija and Salvatore Scianna and Igal Moaraf and Davide Schiavi and Claudia Scardino and No{\'e} Corpataux and Julio Echarte-Morales and Michael Chrissoheris and Estefan{\'i}a Fern{\'a}ndez-Peregrina and {Di Pasquale}, Mattia and Ander Regueiro and Carlos Vergara-Uzcategui and Andres I{\~n}iguez-Romo and Felipe Fern{\'a}ndez-V{\'a}zquez and Danny Dvir and Maurizio Taramasso and Mony Shuvy",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = apr,

day = "22",

doi = "10.3390/jcm10091819",

language = "אנגלית",

volume = "10",

journal = "Journal of Clinical Medicine",

issn = "2077-0383",

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Haberman, D, Estévez-Loureiro, R, Benito-Gonzalez, T, Denti, P, Arzamendi, D, Adamo, M, Freixa, X, Nombela-Franco, L, Villablanca, P, Krivoshei, L, Fam, N, Spargias, K, Czarnecki, A, Pascual, I, Praz, F, Sudarsky, D, Kerner, A, Ninios, V, Gennari, M, Beeri, R, Perl, L, Danenberg, H, Poles, L, Shimoni, S, Goland, S, Caneiro-Queija, B, Scianna, S, Moaraf, I, Schiavi, D, Scardino, C, Corpataux, N, Echarte-Morales, J, Chrissoheris, M, Fernández-Peregrina, E, Di Pasquale, M, Regueiro, A, Vergara-Uzcategui, C, Iñiguez-Romo, A, Fernández-Vázquez, F, Dvir, D, Taramasso, M & Shuvy, M 2021, 'Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction', Journal of Clinical Medicine, vol. 10, no. 9, 1819. https://doi.org/10.3390/jcm10091819

Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction. / Haberman, Dan; Estévez-Loureiro, Rodrigo; Benito-Gonzalez, Tomas et al.
In: Journal of Clinical Medicine, Vol. 10, No. 9, 1819, 22.04.2021.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction

AU - Haberman, Dan

AU - Estévez-Loureiro, Rodrigo

AU - Benito-Gonzalez, Tomas

AU - Denti, Paolo

AU - Arzamendi, Dabit

AU - Adamo, Marianna

AU - Freixa, Xavier

AU - Nombela-Franco, Luis

AU - Villablanca, Pedro

AU - Krivoshei, Lian

AU - Fam, Neil

AU - Spargias, Konstantinos

AU - Czarnecki, Andrew

AU - Pascual, Isaac

AU - Praz, Fabien

AU - Sudarsky, Doron

AU - Kerner, Arthur

AU - Ninios, Vlasis

AU - Gennari, Marco

AU - Beeri, Ronen

AU - Perl, Leor

AU - Danenberg, Haim

AU - Poles, Lion

AU - Shimoni, Sara

AU - Goland, Sorel

AU - Caneiro-Queija, Berenice

AU - Scianna, Salvatore

AU - Moaraf, Igal

AU - Schiavi, Davide

AU - Scardino, Claudia

AU - Corpataux, Noé

AU - Echarte-Morales, Julio

AU - Chrissoheris, Michael

AU - Fernández-Peregrina, Estefanía

AU - Di Pasquale, Mattia

AU - Regueiro, Ander

AU - Vergara-Uzcategui, Carlos

AU - Iñiguez-Romo, Andres

AU - Fernández-Vázquez, Felipe

AU - Dvir, Danny

AU - Taramasso, Maurizio

AU - Shuvy, Mony

PY - 2021/4/22

Y1 - 2021/4/22

N2 - Patients with severe mitral regurgitation (MR) after myocardial infarction (MI) have an increased risk of mortality. Transcatheter mitral valve repair may therefore be a suitable therapy. However, data on clinical outcomes of patients in an acute setting are scarce, especially those with reduced left ventricle (LV) dysfunction. We conducted a multinational, collaborative data analysis from 21 centers for patients who were, within 90 days of acute MI, treated with MitraClip due to severe MR. The cohort was divided according to median left ventricle ejection fraction (LVEF)—35%. Included in the study were 105 patients. The mean age was 71 ± 10 years. Patients in the LVEF < 35% group were younger but with comparable Euroscore II, multivessel coronary artery disease, prior MI and coronary artery bypass graft surgery. Procedure time was comparable and acute success rate was high in both groups (94% vs. 90%, p = 0.728). MR grade was significantly reduced in both groups along with an immediate reduction in left atrial V-wave, pulmonary artery pressure and improvement in New York Heart Association (NYHA) class. In-hospital and 1-year mortality rates were not significantly different between the two groups (11% vs. 7%, p = 0.51 and 19% vs. 12%, p = 0.49) and neither was the 3-month re-hospitalization rate. In conclusion, MitraClip intervention in patients with acute severe functional mitral regurgitation (FMR) due to a recent MI in an acute setting is safe and feasible. Even patients with severe LV dysfunction may benefit from transcatheter mitral valve intervention and should not be excluded.

AB - Patients with severe mitral regurgitation (MR) after myocardial infarction (MI) have an increased risk of mortality. Transcatheter mitral valve repair may therefore be a suitable therapy. However, data on clinical outcomes of patients in an acute setting are scarce, especially those with reduced left ventricle (LV) dysfunction. We conducted a multinational, collaborative data analysis from 21 centers for patients who were, within 90 days of acute MI, treated with MitraClip due to severe MR. The cohort was divided according to median left ventricle ejection fraction (LVEF)—35%. Included in the study were 105 patients. The mean age was 71 ± 10 years. Patients in the LVEF < 35% group were younger but with comparable Euroscore II, multivessel coronary artery disease, prior MI and coronary artery bypass graft surgery. Procedure time was comparable and acute success rate was high in both groups (94% vs. 90%, p = 0.728). MR grade was significantly reduced in both groups along with an immediate reduction in left atrial V-wave, pulmonary artery pressure and improvement in New York Heart Association (NYHA) class. In-hospital and 1-year mortality rates were not significantly different between the two groups (11% vs. 7%, p = 0.51 and 19% vs. 12%, p = 0.49) and neither was the 3-month re-hospitalization rate. In conclusion, MitraClip intervention in patients with acute severe functional mitral regurgitation (FMR) due to a recent MI in an acute setting is safe and feasible. Even patients with severe LV dysfunction may benefit from transcatheter mitral valve intervention and should not be excluded.

KW - Acute myocardial infarction

KW - Left ventricle dysfunction

KW - Mitral regurgitation

KW - Percutaneous mitral valve repair

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U2 - 10.3390/jcm10091819

DO - 10.3390/jcm10091819

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C2 - 33921996

AN - SCOPUS:85114069778

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JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 9

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ER -

Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction

Abstract

Bibliographical note

Keywords

UN SDGs

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