Saliva plays a dual role in oxidation process in stomach medium

S. Gorelik, R. Kohen*, M. Ligumsky, J. Kanner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


The aim of this study was to evaluate the role of saliva in the oxidation process under the acidic condition of the stomach. Saliva specimens played varied roles in the lipid peroxidation process of heated muscle tissue in simulated gastric fluid: pro-oxidant effects, no effects, and antioxidant effects. To elucidate these differences, selected saliva components were examined. The pseudoperoxidase activity of lactoperoxidase increased lipid peroxidation, while thiocyanate and nitrite-reduced lipid peroxidation. The effect of a saliva specimen on lipid peroxidation was correlated with the concentration of nitrite in the specimen, but not with that of other saliva components. The inhibitory effect of nitrite may be due to its conversion to NO. Elucidation of the antioxidant effect of saliva on co-oxidation of d-α-tocopherol in gastric fluid, demonstrated that saliva alone cannot protect d-α-tocopherol from co-oxidation, although it partially protected against lipid peroxidation. The presence of red wine polyphenols in stomach medium totally inhibits food lipid peroxidation and d-α-tocopherol co-oxidation.

Original languageAmerican English
Pages (from-to)236-243
Number of pages8
JournalArchives of Biochemistry and Biophysics
Issue number2
StatePublished - 15 Feb 2007

Bibliographical note

Funding Information:
This research was supported by Research Grant Award IS-3647-04CR from BARD, The United States-Israel Agricultural Research and Development Fund.


  • Antioxidants
  • Lactoperoxidase
  • Lipid peroxidation
  • Nitrite
  • Red wine
  • Saliva
  • Stomach
  • Thiocyanate
  • Uric acid
  • pH


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