Salivary immunoglobulins in recipients of bone marrow grafts III. A longitudinal follow-up of CMV specific antibodies

G. Chaushu, S. Chaushu, S. Slavin, R. Or, A. A. Garfunkel, E. Yefenof*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Cytomegalovirus (CMV) infection is a major complication of BMT. The oral cavity is a common route for CMV infection, whose protection is provided by salivary anti-CMV antibodies. We developed an ELISA assay for the detection of CMV-specific antibodies in parotid saliva. Saliva of patients receiving BMT from CMV-positive donors was transiently reconstituted with IgG and IgA anti-CMV antibodies shortly after transplantation. The concentration of these antibodies gradually decreased during the 2 months after transplantation and increased again around day 80. A remarkable rise in the salivary concentrations of IgG and IgM anti-CMV was observed shortly after i.v. administration of Sandoglobulin. These results demonstrate, for the first time accurate monitoring of CMV-specific antibodies in saliva using a quantitative ELISA assay. The study suggests that secretion of CMV-specific antibodies in saliva of immunocompromised patients can be reconstituted by donor-derived B and plasma cells transferred with the BM or by i.v. administration of pooled Ig.

Original languageAmerican English
Pages (from-to)237-241
Number of pages5
JournalBone Marrow Transplantation
Volume17
Issue number2
StatePublished - Feb 1996
Externally publishedYes

Keywords

  • Bone marrow transplantation
  • CMV
  • MALT
  • Salivary immunoglobulins

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