SARS-CoV-2 Omicron variant emerged under immune selection

Chee Wah Tan; Wan Ni Chia; Feng Zhu; Barnaby E. Young; Napaporn Chantasrisawad; Shi Hsia Hwa; Aileen Ying Yan Yeoh; Beng Lee Lim; Wee Chee Yap; Surinder Kaur M.S. Pada; Seow Yen Tan; Watsamon Jantarabenjakul; Lim Kai Toh; Shiwei Chen; Jinyan Zhang; Yun Yan Mah; Vivian Chih Wei Chen; Mark I.C. Chen; Supaporn Wacharapluesadee; Alex Sigal; Opass Putcharoen; David Chien Lye; Lin Fa Wang

doi:10.1038/s41564-022-01246-1

SARS-CoV-2 Omicron variant emerged under immune selection

Chee Wah Tan^*
, Wan Ni Chia
, Feng Zhu
, Barnaby E. Young
, Napaporn Chantasrisawad
, Shi Hsia Hwa
, Aileen Ying Yan Yeoh
, Beng Lee Lim
, Wee Chee Yap
, Surinder Kaur M.S. Pada
, Seow Yen Tan
, Watsamon Jantarabenjakul
, Lim Kai Toh
, Shiwei Chen
, Jinyan Zhang
, Yun Yan Mah
, Vivian Chih Wei Chen
, Mark I.C. Chen
, Supaporn Wacharapluesadee
, Alex Sigal

Opass Putcharoen, David Chien Lye, Lin Fa Wang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The SARS-CoV-2 Omicron variant (B.1.1.529 lineage) escapes antibodies that neutralize the ancestral virus. We tested human serum panels from participants with differing infection and vaccination status using a multiplex surrogate virus neutralization assay targeting 20 sarbecoviruses. We found that bat and pangolin sarbecoviruses showed significantly less neutralization escape than the Omicron variant. We propose that SARS-CoV-2 variants have emerged under immune selection pressure and are evolving differently from animal sarbecoviruses.

Original language	English
Pages (from-to)	1756-1761
Number of pages	6
Journal	Nature Microbiology
Volume	7
Issue number	11
DOIs	https://doi.org/10.1038/s41564-022-01246-1
State	Published - Nov 2022
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Limited.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/s41564-022-01246-1

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Tan, C. W., Chia, W. N., Zhu, F., Young, B. E., Chantasrisawad, N., Hwa, S. H., Yeoh, A. Y. Y., Lim, B. L., Yap, W. C., Pada, S. K. M. S., Tan, S. Y., Jantarabenjakul, W., Toh, L. K., Chen, S., Zhang, J., Mah, Y. Y., Chen, V. C. W., Chen, M. I. C., Wacharapluesadee, S., ... Wang, L. F. (2022). SARS-CoV-2 Omicron variant emerged under immune selection. Nature Microbiology, 7(11), 1756-1761. https://doi.org/10.1038/s41564-022-01246-1

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title = "SARS-CoV-2 Omicron variant emerged under immune selection",

abstract = "The SARS-CoV-2 Omicron variant (B.1.1.529 lineage) escapes antibodies that neutralize the ancestral virus. We tested human serum panels from participants with differing infection and vaccination status using a multiplex surrogate virus neutralization assay targeting 20 sarbecoviruses. We found that bat and pangolin sarbecoviruses showed significantly less neutralization escape than the Omicron variant. We propose that SARS-CoV-2 variants have emerged under immune selection pressure and are evolving differently from animal sarbecoviruses.",

author = "Tan, \{Chee Wah\} and Chia, \{Wan Ni\} and Feng Zhu and Young, \{Barnaby E.\} and Napaporn Chantasrisawad and Hwa, \{Shi Hsia\} and Yeoh, \{Aileen Ying Yan\} and Lim, \{Beng Lee\} and Yap, \{Wee Chee\} and Pada, \{Surinder Kaur M.S.\} and Tan, \{Seow Yen\} and Watsamon Jantarabenjakul and Toh, \{Lim Kai\} and Shiwei Chen and Jinyan Zhang and Mah, \{Yun Yan\} and Chen, \{Vivian Chih Wei\} and Chen, \{Mark I.C.\} and Supaporn Wacharapluesadee and Alex Sigal and Opass Putcharoen and Lye, \{David Chien\} and Wang, \{Lin Fa\}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature Limited.",

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doi = "10.1038/s41564-022-01246-1",

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Tan, CW, Chia, WN, Zhu, F, Young, BE, Chantasrisawad, N, Hwa, SH, Yeoh, AYY, Lim, BL, Yap, WC, Pada, SKMS, Tan, SY, Jantarabenjakul, W, Toh, LK, Chen, S, Zhang, J, Mah, YY, Chen, VCW, Chen, MIC, Wacharapluesadee, S, Sigal, A, Putcharoen, O, Lye, DC & Wang, LF 2022, 'SARS-CoV-2 Omicron variant emerged under immune selection', Nature Microbiology, vol. 7, no. 11, pp. 1756-1761. https://doi.org/10.1038/s41564-022-01246-1

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AU - Tan, Chee Wah

AU - Chia, Wan Ni

AU - Zhu, Feng

AU - Young, Barnaby E.

AU - Chantasrisawad, Napaporn

AU - Hwa, Shi Hsia

AU - Yeoh, Aileen Ying Yan

AU - Lim, Beng Lee

AU - Yap, Wee Chee

AU - Pada, Surinder Kaur M.S.

AU - Tan, Seow Yen

AU - Jantarabenjakul, Watsamon

AU - Toh, Lim Kai

AU - Chen, Shiwei

AU - Zhang, Jinyan

AU - Mah, Yun Yan

AU - Chen, Vivian Chih Wei

AU - Chen, Mark I.C.

AU - Wacharapluesadee, Supaporn

AU - Sigal, Alex

AU - Putcharoen, Opass

AU - Lye, David Chien

AU - Wang, Lin Fa

PY - 2022/11

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SARS-CoV-2 Omicron variant emerged under immune selection

Abstract

Bibliographical note

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