TY - JOUR
T1 - Saturable Processes Affecting Renal Clearance of Cefixime in Dogs
AU - Tonelli, Alfred P.
AU - Bialer, Meir
AU - Look, Zee M.
AU - Carson, Steven
AU - Yacobi, Avraham
PY - 1986/6
Y1 - 1986/6
N2 - The pharmacokinetics of cefixime, a new orally active cephalosporin, was studied after an intravenous dose of 50 mg/kg to four beagle dogs. Cefixime was shown to exhibit concentration dependent serum protein binding and saturable tubular reabsorption. The drug was excreted mainly in the urine, the net result of glomerular filtration and saturable tubular reabsorption. The experimental results were analyzed by model independent pharmacokinetic equations and with theoretical models describing renal clearance. Modification of the models, based on observed data, was proposed. The experimental methods employed and the pharmacokinetic approach offered in this study can be applied to drugs that exhibit concentration dependent protein binding and saturable renal elimination processes.
AB - The pharmacokinetics of cefixime, a new orally active cephalosporin, was studied after an intravenous dose of 50 mg/kg to four beagle dogs. Cefixime was shown to exhibit concentration dependent serum protein binding and saturable tubular reabsorption. The drug was excreted mainly in the urine, the net result of glomerular filtration and saturable tubular reabsorption. The experimental results were analyzed by model independent pharmacokinetic equations and with theoretical models describing renal clearance. Modification of the models, based on observed data, was proposed. The experimental methods employed and the pharmacokinetic approach offered in this study can be applied to drugs that exhibit concentration dependent protein binding and saturable renal elimination processes.
KW - cefixime
KW - cephalosporin
KW - pharmacokinetics
KW - renal clearance
KW - saturable protein binding
KW - tubular reabsorption
UR - http://www.scopus.com/inward/record.url?scp=0023028787&partnerID=8YFLogxK
U2 - 10.1023/A:1016309923717
DO - 10.1023/A:1016309923717
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AN - SCOPUS:0023028787
SN - 0724-8741
VL - 3
SP - 150
EP - 155
JO - Pharmaceutical Research
JF - Pharmaceutical Research
IS - 3
ER -