Schizophrenia patients differentiation based on MR vascular perfusion and volumetric imaging

A. B. Spanier*, L. Joskowicz, S. Moshel, D. Israeli

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Candecomp/Parafac Decomposition (CPD) has emerged as a framework for modeling N-way arrays (higher-order matrices). CPD is naturally well suited for the analysis of data sets comprised of observations of a function of multiple discrete indices. In this study we evaluate the prospects of using CPD for modeling MRI brain properties (i.e. brain volume and gray-level) for schizophrenia diagnosis. Taking into account that 3D imaging data consists of millions of pixels per patient, the diagnosis of a schizophrenia patient based on pixel analysis constitutes a methodological challenge (e.g. multiple comparison problem). We show that the CPD could potentially be used as a dimensionality redaction method and as a discriminator between schizophrenia patients and match control, using the gradient of pre-and post Gd-T1-weighted MRI data, which is strongly correlated with cerebral blood perfusion. Our approach was tested on 68 MRI scans: 40 first-episode schizophrenia patients and 28 matched controls. The CPD subject"s scores exhibit statistically significant result (P < 0.001). In the context of diagnosing schizophrenia with MRI, the results suggest that the CPD could potentially be used to discriminate between schizophrenia patients and matched control. In addition, the CPD model suggests for brain regions that might exhibit abnormalities in schizophrenia patients for future research.

Original languageAmerican English
Title of host publicationMedical Imaging 2015
Subtitle of host publicationImage Processing
EditorsMartin A. Styner, Sebastien Ourselin
PublisherSPIE
ISBN (Electronic)9781628415032
DOIs
StatePublished - 2015
EventMedical Imaging 2015: Image Processing - Orlando, United States
Duration: 24 Feb 201526 Feb 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9413
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2015: Image Processing
Country/TerritoryUnited States
CityOrlando
Period24/02/1526/02/15

Bibliographical note

Publisher Copyright:
© 2015 SPIE.

Keywords

  • Candecomp/Parafac Decomposition (CPD)
  • MRI
  • Morbid schizophrenia
  • multiple comparisons problem (MCP)

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