Abstract
Swelling and diffusion experiments, performed in vitro with tablets prepared with scleroglucan and several hydrophilic and hydrophobic additives, indicate that it is possible to modulate drug delivery from the matrix by appropriate choice of the nature and amount of the additive. The additives in the formulations may affect the mechanisms (zero order, diffusion, erosion) involved in the release of drugs from the dosage forms.
Original language | English |
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Pages (from-to) | 249-257 |
Number of pages | 9 |
Journal | Drug Design and Delivery |
Volume | 5 |
Issue number | 3 |
State | Published - 1990 |
Externally published | Yes |
Keywords
- additives
- release mechanisms
- scleroglucan
- sustained release