Scleroglucan sustained release oral preparations. Part II. Effects of additives

F. Alhaique, E. Beltrami, F. M. Riccieri, E. Santucci, E. Touitou

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Swelling and diffusion experiments, performed in vitro with tablets prepared with scleroglucan and several hydrophilic and hydrophobic additives, indicate that it is possible to modulate drug delivery from the matrix by appropriate choice of the nature and amount of the additive. The additives in the formulations may affect the mechanisms (zero order, diffusion, erosion) involved in the release of drugs from the dosage forms.

Original languageEnglish
Pages (from-to)249-257
Number of pages9
JournalDrug Design and Delivery
Volume5
Issue number3
StatePublished - 1990
Externally publishedYes

Keywords

  • additives
  • release mechanisms
  • scleroglucan
  • sustained release

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