Two T-cell receptor (TCR) populations are expressed on T cells; one is linked to the cytoskeleton via its ζ chain. These cytoskeleton-linked receptors (30-40% of the total number of TCRs) might be important in TCR-mediated signaling and/or concurrent events. Here, differences between the two populations are summarized, and new data are examined to speculate on the functional significance of cytoskeleton-linked TCRs.
Bibliographical noteFunding Information:
We thank G. Berke, L. Wang and N. Naslavsky for their critical advice, and acknowledge the support of the Society for Research Associates of the Lautenberg Center, the United States-Israel Binational Science Foundation, the Concern Foundation of Los Angeles and the Abisch-Frankel Foundation for the Life Sciences. We apologize that owing to space constraints we were unable to cite all of the many relevant references in this rapidly growing field.