Searching for significance in TCR-cytoskeleton interactions

Steve Caplan*, Michal Baniyash

*Corresponding author for this work

Research output: Contribution to journalComment/debate

28 Scopus citations


Two T-cell receptor (TCR) populations are expressed on T cells; one is linked to the cytoskeleton via its ζ chain. These cytoskeleton-linked receptors (30-40% of the total number of TCRs) might be important in TCR-mediated signaling and/or concurrent events. Here, differences between the two populations are summarized, and new data are examined to speculate on the functional significance of cytoskeleton-linked TCRs.

Original languageAmerican English
Pages (from-to)223-228
Number of pages6
JournalImmunology Today
Issue number5
StatePublished - 2000

Bibliographical note

Funding Information:
We thank G. Berke, L. Wang and N. Naslavsky for their critical advice, and acknowledge the support of the Society for Research Associates of the Lautenberg Center, the United States-Israel Binational Science Foundation, the Concern Foundation of Los Angeles and the Abisch-Frankel Foundation for the Life Sciences. We apologize that owing to space constraints we were unable to cite all of the many relevant references in this rapidly growing field.


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