Searching for significance in TCR-cytoskeleton interactions

Steve Caplan; Michal Baniyash

doi:10.1016/S0167-5699(00)01604-2

Searching for significance in TCR-cytoskeleton interactions

Steve Caplan^*, Michal Baniyash

^*Corresponding author for this work

Department of Immunology and Cancer Research

Research output: Contribution to journal › Comment/debate

28 Scopus citations

Abstract

Two T-cell receptor (TCR) populations are expressed on T cells; one is linked to the cytoskeleton via its ζ chain. These cytoskeleton-linked receptors (30-40% of the total number of TCRs) might be important in TCR-mediated signaling and/or concurrent events. Here, differences between the two populations are summarized, and new data are examined to speculate on the functional significance of cytoskeleton-linked TCRs.

Original language	English
Pages (from-to)	223-228
Number of pages	6
Journal	Immunology Today
Volume	21
Issue number	5
DOIs	https://doi.org/10.1016/S0167-5699(00)01604-2
State	Published - 2000

Bibliographical note

Funding Information:
We thank G. Berke, L. Wang and N. Naslavsky for their critical advice, and acknowledge the support of the Society for Research Associates of the Lautenberg Center, the United States-Israel Binational Science Foundation, the Concern Foundation of Los Angeles and the Abisch-Frankel Foundation for the Life Sciences. We apologize that owing to space constraints we were unable to cite all of the many relevant references in this rapidly growing field.

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title = "Searching for significance in TCR-cytoskeleton interactions",

abstract = "Two T-cell receptor (TCR) populations are expressed on T cells; one is linked to the cytoskeleton via its ζ chain. These cytoskeleton-linked receptors (30-40% of the total number of TCRs) might be important in TCR-mediated signaling and/or concurrent events. Here, differences between the two populations are summarized, and new data are examined to speculate on the functional significance of cytoskeleton-linked TCRs.",

author = "Steve Caplan and Michal Baniyash",

note = "Funding Information: We thank G. Berke, L. Wang and N. Naslavsky for their critical advice, and acknowledge the support of the Society for Research Associates of the Lautenberg Center, the United States-Israel Binational Science Foundation, the Concern Foundation of Los Angeles and the Abisch-Frankel Foundation for the Life Sciences. We apologize that owing to space constraints we were unable to cite all of the many relevant references in this rapidly growing field.",

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doi = "10.1016/S0167-5699(00)01604-2",

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AU - Baniyash, Michal

N1 - Funding Information: We thank G. Berke, L. Wang and N. Naslavsky for their critical advice, and acknowledge the support of the Society for Research Associates of the Lautenberg Center, the United States-Israel Binational Science Foundation, the Concern Foundation of Los Angeles and the Abisch-Frankel Foundation for the Life Sciences. We apologize that owing to space constraints we were unable to cite all of the many relevant references in this rapidly growing field.

PY - 2000

Y1 - 2000

N2 - Two T-cell receptor (TCR) populations are expressed on T cells; one is linked to the cytoskeleton via its ζ chain. These cytoskeleton-linked receptors (30-40% of the total number of TCRs) might be important in TCR-mediated signaling and/or concurrent events. Here, differences between the two populations are summarized, and new data are examined to speculate on the functional significance of cytoskeleton-linked TCRs.

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Searching for significance in TCR-cytoskeleton interactions

Abstract

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