Second messengers involved in the response of gonadotropic hormone (GtH) cells in fish: GtH release and GtH IIβ mRNA levels

Zvi Yaron*, Berta Levavi-Sivan, Philippa Melamed, Hanna Rosenfeld, Abigail Elizur

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The transduction of the GnRH signal in teleost fish involves G-proteins, phospholipase C, diacylglycerol, inositol trisphoshate, Ca2+ influx and mobilization from intracellular sources, calmodulin, protein kinase C, phospholipase A2, arachidonic acid and its cycloxygenase metabolites. In certain fish cyclic AMP and PKA are also involved in the transduction. Dopamine exerts its inhibitory effect on Ca2+ influx, at a site proximal to Ca2+ mobilization, at sites distal to PKC and PKA and at a site proximal to arachidonic acid. GnRH, through PKC and PKA, increases the steady-state level of GtH IIβ mRNA in tilapia. One of the modes of cAMP action is the stabilization of this mRNA.

Original languageEnglish
Pages (from-to)254-259
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume839
DOIs
StatePublished - 15 May 1998
Externally publishedYes

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