Second messengers involved in the response of gonadotropic hormone (GtH) cells in fish: GtH release and GtH IIβ mRNA levels

Zvi Yaron; Berta Levavi-Sivan; Philippa Melamed; Hanna Rosenfeld; Abigail Elizur

doi:10.1111/j.1749-6632.1998.tb10770.x

Second messengers involved in the response of gonadotropic hormone (GtH) cells in fish: GtH release and GtH IIβ mRNA levels

Zvi Yaron^*, Berta Levavi-Sivan, Philippa Melamed, Hanna Rosenfeld, Abigail Elizur

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The transduction of the GnRH signal in teleost fish involves G-proteins, phospholipase C, diacylglycerol, inositol trisphoshate, Ca²⁺ influx and mobilization from intracellular sources, calmodulin, protein kinase C, phospholipase A₂, arachidonic acid and its cycloxygenase metabolites. In certain fish cyclic AMP and PKA are also involved in the transduction. Dopamine exerts its inhibitory effect on Ca²⁺ influx, at a site proximal to Ca²⁺ mobilization, at sites distal to PKC and PKA and at a site proximal to arachidonic acid. GnRH, through PKC and PKA, increases the steady-state level of GtH IIβ mRNA in tilapia. One of the modes of cAMP action is the stabilization of this mRNA.

Original language	English
Pages (from-to)	254-259
Number of pages	6
Journal	Annals of the New York Academy of Sciences
Volume	839
DOIs	https://doi.org/10.1111/j.1749-6632.1998.tb10770.x
State	Published - 15 May 1998
Externally published	Yes

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title = "Second messengers involved in the response of gonadotropic hormone (GtH) cells in fish: GtH release and GtH IIβ mRNA levels",

abstract = "The transduction of the GnRH signal in teleost fish involves G-proteins, phospholipase C, diacylglycerol, inositol trisphoshate, Ca2+ influx and mobilization from intracellular sources, calmodulin, protein kinase C, phospholipase A2, arachidonic acid and its cycloxygenase metabolites. In certain fish cyclic AMP and PKA are also involved in the transduction. Dopamine exerts its inhibitory effect on Ca2+ influx, at a site proximal to Ca2+ mobilization, at sites distal to PKC and PKA and at a site proximal to arachidonic acid. GnRH, through PKC and PKA, increases the steady-state level of GtH IIβ mRNA in tilapia. One of the modes of cAMP action is the stabilization of this mRNA.",

author = "Zvi Yaron and Berta Levavi-Sivan and Philippa Melamed and Hanna Rosenfeld and Abigail Elizur",

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AU - Melamed, Philippa

AU - Rosenfeld, Hanna

AU - Elizur, Abigail

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AB - The transduction of the GnRH signal in teleost fish involves G-proteins, phospholipase C, diacylglycerol, inositol trisphoshate, Ca2+ influx and mobilization from intracellular sources, calmodulin, protein kinase C, phospholipase A2, arachidonic acid and its cycloxygenase metabolites. In certain fish cyclic AMP and PKA are also involved in the transduction. Dopamine exerts its inhibitory effect on Ca2+ influx, at a site proximal to Ca2+ mobilization, at sites distal to PKC and PKA and at a site proximal to arachidonic acid. GnRH, through PKC and PKA, increases the steady-state level of GtH IIβ mRNA in tilapia. One of the modes of cAMP action is the stabilization of this mRNA.

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Second messengers involved in the response of gonadotropic hormone (GtH) cells in fish: GtH release and GtH IIβ mRNA levels

Abstract

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