TY - JOUR
T1 - Second messengers involved in the response of gonadotropic hormone (GtH) cells in fish
T2 - GtH release and GtH IIβ mRNA levels
AU - Yaron, Zvi
AU - Levavi-Sivan, Berta
AU - Melamed, Philippa
AU - Rosenfeld, Hanna
AU - Elizur, Abigail
PY - 1998/5/15
Y1 - 1998/5/15
N2 - The transduction of the GnRH signal in teleost fish involves G-proteins, phospholipase C, diacylglycerol, inositol trisphoshate, Ca2+ influx and mobilization from intracellular sources, calmodulin, protein kinase C, phospholipase A2, arachidonic acid and its cycloxygenase metabolites. In certain fish cyclic AMP and PKA are also involved in the transduction. Dopamine exerts its inhibitory effect on Ca2+ influx, at a site proximal to Ca2+ mobilization, at sites distal to PKC and PKA and at a site proximal to arachidonic acid. GnRH, through PKC and PKA, increases the steady-state level of GtH IIβ mRNA in tilapia. One of the modes of cAMP action is the stabilization of this mRNA.
AB - The transduction of the GnRH signal in teleost fish involves G-proteins, phospholipase C, diacylglycerol, inositol trisphoshate, Ca2+ influx and mobilization from intracellular sources, calmodulin, protein kinase C, phospholipase A2, arachidonic acid and its cycloxygenase metabolites. In certain fish cyclic AMP and PKA are also involved in the transduction. Dopamine exerts its inhibitory effect on Ca2+ influx, at a site proximal to Ca2+ mobilization, at sites distal to PKC and PKA and at a site proximal to arachidonic acid. GnRH, through PKC and PKA, increases the steady-state level of GtH IIβ mRNA in tilapia. One of the modes of cAMP action is the stabilization of this mRNA.
UR - http://www.scopus.com/inward/record.url?scp=0032524549&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.1998.tb10770.x
DO - 10.1111/j.1749-6632.1998.tb10770.x
M3 - Article
AN - SCOPUS:0032524549
SN - 0077-8923
VL - 839
SP - 254
EP - 259
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -