Second transplantation using allogeneic peripheral blood stem cells in a β-thalassaemia major patient featuring stable mixed chimaerism

R. Or; J. Kapelushnik; E. Naparstek; A. Nagler; D. Filon; A. Oppenheim; A. Amar; M. Aker; S. Samuel; S. Slavin

doi:10.1046/j.1365-2141.1996.d01-1797.x

Second transplantation using allogeneic peripheral blood stem cells in a β-thalassaemia major patient featuring stable mixed chimaerism

R. Or^*, J. Kapelushnik, E. Naparstek, A. Nagler, D. Filon, A. Oppenheim, A. Amar, M. Aker, S. Samuel, S. Slavin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Allogeneic bone marrow transplantation (BMT) for β-thalassaemia major carries the risks of disease recurrence due to residual thalassaemic stem cells or true immune-mediated rejection. We report a thalassaemic patient who displayed stable mixed chimaerism with only 5% donor-derived cells for about 5 years after BMT. Displacement of host cells was accomplished by ambulatory non-myeloablative conditioning and allogeneic G-CSF mobilized peripheral blood stem cell transplantation from the same donor, resulting in full reconstitution. Patients featuring stable mixed chimaerism after BMT may benefit from allogeneic cell therapy with immunocompetent lymphocytes and stem cells, whilst avoiding supralethal conditioning.

Original language	English
Pages (from-to)	285-287
Number of pages	3
Journal	British Journal of Haematology
Volume	94
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2141.1996.d01-1797.x
State	Published - 1996
Externally published	Yes

Keywords

bone marrow transplantation
peripheral blood stem cell transplantation
stable mixed chimaerism
β-globin gene
β-thalassaemia major

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10.1046/j.1365-2141.1996.d01-1797.x

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title = "Second transplantation using allogeneic peripheral blood stem cells in a β-thalassaemia major patient featuring stable mixed chimaerism",

abstract = "Allogeneic bone marrow transplantation (BMT) for β-thalassaemia major carries the risks of disease recurrence due to residual thalassaemic stem cells or true immune-mediated rejection. We report a thalassaemic patient who displayed stable mixed chimaerism with only 5% donor-derived cells for about 5 years after BMT. Displacement of host cells was accomplished by ambulatory non-myeloablative conditioning and allogeneic G-CSF mobilized peripheral blood stem cell transplantation from the same donor, resulting in full reconstitution. Patients featuring stable mixed chimaerism after BMT may benefit from allogeneic cell therapy with immunocompetent lymphocytes and stem cells, whilst avoiding supralethal conditioning.",

keywords = "bone marrow transplantation, peripheral blood stem cell transplantation, stable mixed chimaerism, β-globin gene, β-thalassaemia major",

author = "R. Or and J. Kapelushnik and E. Naparstek and A. Nagler and D. Filon and A. Oppenheim and A. Amar and M. Aker and S. Samuel and S. Slavin",

year = "1996",

doi = "10.1046/j.1365-2141.1996.d01-1797.x",

language = "אנגלית",

volume = "94",

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journal = "British Journal of Haematology",

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Or, R, Kapelushnik, J, Naparstek, E, Nagler, A, Filon, D, Oppenheim, A, Amar, A, Aker, M, Samuel, S & Slavin, S 1996, 'Second transplantation using allogeneic peripheral blood stem cells in a β-thalassaemia major patient featuring stable mixed chimaerism', British Journal of Haematology, vol. 94, no. 2, pp. 285-287. https://doi.org/10.1046/j.1365-2141.1996.d01-1797.x

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AU - Or, R.

AU - Kapelushnik, J.

AU - Naparstek, E.

AU - Nagler, A.

AU - Filon, D.

AU - Oppenheim, A.

AU - Amar, A.

AU - Aker, M.

AU - Samuel, S.

AU - Slavin, S.

PY - 1996

Y1 - 1996

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AB - Allogeneic bone marrow transplantation (BMT) for β-thalassaemia major carries the risks of disease recurrence due to residual thalassaemic stem cells or true immune-mediated rejection. We report a thalassaemic patient who displayed stable mixed chimaerism with only 5% donor-derived cells for about 5 years after BMT. Displacement of host cells was accomplished by ambulatory non-myeloablative conditioning and allogeneic G-CSF mobilized peripheral blood stem cell transplantation from the same donor, resulting in full reconstitution. Patients featuring stable mixed chimaerism after BMT may benefit from allogeneic cell therapy with immunocompetent lymphocytes and stem cells, whilst avoiding supralethal conditioning.

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KW - peripheral blood stem cell transplantation

KW - stable mixed chimaerism

KW - β-globin gene

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Second transplantation using allogeneic peripheral blood stem cells in a β-thalassaemia major patient featuring stable mixed chimaerism

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Keywords

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