Selective binding of the scorpion venom insect toxin to insect nervous tissue

Z. Teitelbaum*, P. Lazarovici, E. Zlotkin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Insect toxin (IT), a highly lethal and paralytic protein purified from scorpion venom, has been used in binding experiments with different tissue preparations of Locusta migratoria. A clear, specific binding of a high affinity was obtained only between the radio-iodinated toxin and the nervous tissue extracts. Assays with a similar nervous tissue preparation derived from a crustacean (crayfish) resulted in a low and non-specific binding of the toxin. The present data support the notion of a selective action of IT on insect nervous tissue and may indicate a certain structural uniqueness in this system.

Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalInsect Biochemistry
Volume9
Issue number4
DOIs
StatePublished - 1979

Keywords

  • insect toxin
  • Locusta
  • nervous tissue
  • radio-iodination
  • scorpion venom
  • selective action
  • specific binding

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