Selective Electrooxidation of 4-(Di-n-propylsulfamyl)toluene to 4-(Di-n-propylsulfamyl)benzoic acid

M. Michman, M. Weiss

Research output: Contribution to journalArticlepeer-review

Abstract

4-(Di-n-propylsulfamyl)benzoic acid is an important drug, known under commercial names such as benemid or probenecid [1]. It's preparation under mild conditions by an electrochemical method is described. The method involves cathodic generated oxygen radical-anion which selectively converts the methyl group of 4-(Di-n-propylsulfamyl)toluene to carboxylate. The sulfonamide group which would be reduced under high cathodic potential is not attacked under these conditions. This method circumvents safety problems and the need for corrosive reagents involved in chemical methods of preparation.

Original languageEnglish
Pages (from-to)667-673
Number of pages7
JournalStudies in Surface Science and Catalysis
Volume55
Issue numberC
DOIs
StatePublished - 1 Jan 1990

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