Selective reduction of adrenal medulla response to angiotensin induced by suppression of renin-angiotensin

Michal Mazur-Ruder; Giora Feuerstein; Doron Roll; Yehuda Gutman

doi:10.1016/0014-2999(79)90289-9

Selective reduction of adrenal medulla response to angiotensin induced by suppression of renin-angiotensin

Michal Mazur-Ruder, Giora Feuerstein, Doron Roll, Yehuda Gutman^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Angiotensin II (AII) induced an increase of adrenaline (A) release from rat adrenal glands in vitro. The response of the adrenal glands was completely abolished 22-24 after bilateral nephrectomy. Adrenal glands from DOCA-salt-treated rats did not respond to AII as well, whereas adrenal glands from rats treated with furosemide and a low salt diet retained this response. High potassium in the medium increased significantly the release of A from in vitro incubated adrenal glandsof nephrectomized rats from 0.43 ± 0.04 to 0.63 ± 0.06 μg/gland and salbutamol (in calcium-free medium) increased the release from 0.34 ± 0.03 to 0.43 ± 0.03 μg/gland. These results indicate that the adrenal medulla develops subsensitivity to AII in vitro, following a reduction in levels of this agonist in vivo.

Original language	English
Pages (from-to)	261-266
Number of pages	6
Journal	European Journal of Pharmacology
Volume	59
Issue number	3-4
DOIs	https://doi.org/10.1016/0014-2999(79)90289-9
State	Published - 16 Nov 1979

Keywords

Adrenal medulla
Adrenaline
Angiotensin
DOCA
Nephrectomy
Salbutamol

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10.1016/0014-2999(79)90289-9

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title = "Selective reduction of adrenal medulla response to angiotensin induced by suppression of renin-angiotensin",

abstract = "Angiotensin II (AII) induced an increase of adrenaline (A) release from rat adrenal glands in vitro. The response of the adrenal glands was completely abolished 22-24 after bilateral nephrectomy. Adrenal glands from DOCA-salt-treated rats did not respond to AII as well, whereas adrenal glands from rats treated with furosemide and a low salt diet retained this response. High potassium in the medium increased significantly the release of A from in vitro incubated adrenal glandsof nephrectomized rats from 0.43 ± 0.04 to 0.63 ± 0.06 μg/gland and salbutamol (in calcium-free medium) increased the release from 0.34 ± 0.03 to 0.43 ± 0.03 μg/gland. These results indicate that the adrenal medulla develops subsensitivity to AII in vitro, following a reduction in levels of this agonist in vivo.",

keywords = "Adrenal medulla, Adrenaline, Angiotensin, DOCA, Nephrectomy, Salbutamol",

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AU - Mazur-Ruder, Michal

AU - Feuerstein, Giora

AU - Roll, Doron

AU - Gutman, Yehuda

PY - 1979/11/16

Y1 - 1979/11/16

N2 - Angiotensin II (AII) induced an increase of adrenaline (A) release from rat adrenal glands in vitro. The response of the adrenal glands was completely abolished 22-24 after bilateral nephrectomy. Adrenal glands from DOCA-salt-treated rats did not respond to AII as well, whereas adrenal glands from rats treated with furosemide and a low salt diet retained this response. High potassium in the medium increased significantly the release of A from in vitro incubated adrenal glandsof nephrectomized rats from 0.43 ± 0.04 to 0.63 ± 0.06 μg/gland and salbutamol (in calcium-free medium) increased the release from 0.34 ± 0.03 to 0.43 ± 0.03 μg/gland. These results indicate that the adrenal medulla develops subsensitivity to AII in vitro, following a reduction in levels of this agonist in vivo.

AB - Angiotensin II (AII) induced an increase of adrenaline (A) release from rat adrenal glands in vitro. The response of the adrenal glands was completely abolished 22-24 after bilateral nephrectomy. Adrenal glands from DOCA-salt-treated rats did not respond to AII as well, whereas adrenal glands from rats treated with furosemide and a low salt diet retained this response. High potassium in the medium increased significantly the release of A from in vitro incubated adrenal glandsof nephrectomized rats from 0.43 ± 0.04 to 0.63 ± 0.06 μg/gland and salbutamol (in calcium-free medium) increased the release from 0.34 ± 0.03 to 0.43 ± 0.03 μg/gland. These results indicate that the adrenal medulla develops subsensitivity to AII in vitro, following a reduction in levels of this agonist in vivo.

KW - Adrenal medulla

KW - Adrenaline

KW - Angiotensin

KW - DOCA

KW - Nephrectomy

KW - Salbutamol

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ER -

Selective reduction of adrenal medulla response to angiotensin induced by suppression of renin-angiotensin

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Keywords

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